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Table 1 Experimental validation of predicted anti-malarial single agent compounds

From: A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria

Compound Class
3D7
Class
DD2
Class
HB3
AC50
3D7
AC50
DD2
AC50
HB3
Average AC50
CHR 1.1 1.1 1.1 0.0119 0.0106 0.0106 0.011
FUL 1.1 1.1 1.1 0.0335 0.0335 0.1332 0.0667
API 1.1 1.1 1.1 0.0749 0.0841 0.0749 0.078
ING 1.1 1.1 1.1 1.3324 1.495 1.495 1.4408
MON − 2.1 − 2.1 − 2.3 1.4956 1.0588 1.8828 1.4791
RAL 1.1 1.1 − 2.1 0.7493 0.3347 4.7277 1.9372
TAC 1.1 1.1 1.1 1.8821 3.7553 1.6774 2.4383
CHE 1.3 − 2.3 1.3 0.0266 10.5839 0.0011 3.5372
JX4 1.1 1.1 − 2.1 0.7493 0.0595 10.5839 3.7976
HYD 1.1 1.1 − 2.1 2.6586 1.6774 11.8754 5.4038
THI − 2.1 − 2.1 − 2.1 10.5839 14.9502 14.9502 13.4948
MEG − 2.1 − 1.1 − 2.1 14.9502 1.8821 23.6945 13.5089
PI8 − 2.3 − 2.1 − 2.1 13.3244 11.8754 16.7744 13.9914
KIN − 2.1 − 2.1 − 2.1 13.3244 21.1177 16.7744 17.0722
  1. The fitted AC50 values (µM) for the single drugs as well as classes of activity are listed. AC50 indicates 50% maximal response (for inhibition or agonism) and is calculated by fitting a 4-parameter logistic model to the concentration, response data. Curve classes are defined in Additional file 2: Figure S1
  2. Classes that are identified as −1.1 are highlighted in italics as it signifies complete curve as well as high efficacy