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Table 2 Synergy prediction and synergy scores based on experiments

From: A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria

Compund 1 Compound 2 3D7
Pred
3D7
Gamma
DD2
Pred
DD2
Gamma
HB3
Pred
HB3
Gamma
TAC HYD 0.309 0.948** 0.189 0.885** 0.501 0.951*
FUL TAC 0.627 0.961* 0.612 0.908** 0.659 0.989
ING TAC 0.820 0.954* 0.674 0.917** 0.854 0.954*
FUL MEG 0.722 1.007 0.583 0.918** 0.745 0.970*
MEG HYD 0.784 0.985 0.629 0.920** 0.738 0.988
KIN HYD 0.475 0.984 0.371 0.938** 0.477 0.977
API TAC 0.416 0.975* 0.685 0.942** 0.523 0.946**
FUL RAL 0.792 0.980 0.739 0.952* 0.825 0.966*
API HYD 0.806 0.987 0.717 0.952* 0.501 0.968*
FUL THI 0.651 0.982 0.714 0.954* 0.540 0.960*
THI RAL 0.549 0.931** 0.698 0.956* 0.375 0.911**
PI8 HYD 0.278 0.977 0.293 0.961* 0.171 0.993
FUL HYD 0.788 0.965* 0.747 0.962* 0.734 0.951*
TAC RAL 0.483 0.995 0.342 0.964* 0.612 0.962*
ING JX4 0.859 0.980 0.740 0.968* 0.826 0.975*
MEG RAL 0.795 0.937** 0.648 0.969* 0.791 0.966*
ING RAL 0.836 0.964* 0.658 0.975* 0.793 0.966*
API RAL 0.814 0.997 0.697 0.976 0.472 0.992
CHR HYD 0.633 1.001 0.238 0.979 0.644 0.991
KIN JX4 0.510 0.987 0.530 0.982 0.479 0.989
API JX4 0.761 1.020 0.723 0.984 0.495 0.970*
CHR TAC 0.418 0.99 0.163 0.987 0.445 0.996
JX4 HYD 0.498 0.984 0.503 0.987 0.498 0.986
PI8 ING 0.551 0.975* 0.443 0.991 0.499 0.989
PI8 JX4 0.238 0.990 0.621 0.994 0.214 0.981
PI8 RAL 0.369 1.014 0.293 0.997 0.126 0.995
CHR JX4 0.709 0.990 0.355 0.999 0.608 0.991
API MEG 0.776 0.981 0.632 1.004 0.582 0.979
CHR MEG 0.817 0.995 0.568 1.010 0.791 0.985
PI8 TAC 0.283 0.986 0.205 1.014 0.118 0.983
API CHR 0.785 0.999 0.722 1.014 0.525 0.998
CHR RAL 0.785 0.990 0.442 1.019 0.695 1.004
PI8 MEG 0.491 0.972* 0.366 1.021 0.272 0.966*
ING HYD 0.869 0.985 0.699 1.021 0.810 0.992
PI8 KIN 0.246 0.989 0.348 1.046 0.197 0.997
  1. This table represents gamma (γ) values as a metric for calculation of synergy as well as predicted probability of synergy for three different P. falciparum strains. Values of γ ≤ 0.95 represent strong synergy and were marked with ** and italic. Values of 0.95 < http < 0.975 were identified as moderate synergy and marked with * and italic, 0.975 < γ < 0.995 were identified as mild synergy and marked with italic font. Prediction scores above 0.5 were true predictions and were marked with italic font