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Table 5 Maximum plasma concentration of experimentally validated single agents with activity against malaria

From: A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria

Compound Maximum plasma concentration, CMax (ng/mL) Molar mass (g/mol) Maximal dose (nM) Refs
FUL 12.6 606.772 20.8 [53]
RAL 1 473.584 2.1 [54]
THI 205.5 370.577 554 [55]
MEG 412 384.516 1071 [56]
TAC 15.8 804.018 19.6 [57]
HYD 32 374.904 85.3 [58]
API 341.6 ± 85.2 623.79 547.6 ± 136.6 [59]
CHR 1.85 1183.25 1.5 [60]