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Table 5 Maximum plasma concentration of experimentally validated single agents with activity against malaria

From: A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria

Compound

Maximum plasma concentration, CMax (ng/mL)

Molar mass (g/mol)

Maximal dose (nM)

Refs

FUL

12.6

606.772

20.8

[53]

RAL

1

473.584

2.1

[54]

THI

205.5

370.577

554

[55]

MEG

412

384.516

1071

[56]

TAC

15.8

804.018

19.6

[57]

HYD

32

374.904

85.3

[58]

API

341.6 ± 85.2

623.79

547.6 ± 136.6

[59]

CHR

1.85

1183.25

1.5

[60]