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Fig. 4 | Malaria Journal

Fig. 4

From: Simulation models predict that school-age children are responsible for most human-to-mosquito Plasmodium falciparum transmission in southern Malawi

Fig. 4

Predicted transmission contributions in a sensitivity analysis varying human-to-mosquito infectivity (κ a ) by age. Infectivity to mosquitoes may vary with human age in relation to differences in recent antimalarial treatment, treatment-blocking immunity, duration of infection, multiplicity of infection, or other unknown factors, all of which could differ with age, even after accounting for gametocyte presence and density. Thus a sensitivity analysis was performed for transmission contribution when varying infectivity by age with outside bounds informed by the scientific literature on membrane feeding experiments that accounted for gametocyte status. Infectivity of children under 5 years and school-age children were varied relative to the infectivity of young adults (16–30 years)

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