Differential susceptibilities of Anopheles albimanus and Anopheles stephensi mosquitoes to ivermectin

Malaria Journal

Table 3 Survival and fecundity of Anopheles mosquitoes at 6 days after feeding on ivermectin treated versus untreated mice

Species	Treatment	1 day after mouse injections				3 days after mouse injections
Species	Treatment	Percent surviving (n)		Eggs per female (± SD)		Percent surviving (n)		Eggs per female (± SD)
An. stephensi	Ivermectin	15% (52)	cχ² = 76.5 p < 0.001	0.9 ± 1.6	T = 8.2 df = 13 p < 0.001	62% (66)	cχ² = 15.7 p < 0.001	30.8 ± 8.7	T = 1.0 df = 4 p = 0.373
An. stephensi	Control	100% (56)	cχ² = 76.5 p < 0.001	46.1 ± 25.9	T = 8.2 df = 13 p < 0.001	96% (48)	cχ² = 15.7 p < 0.001	44.7 ± 18.8	T = 1.0 df = 4 p = 0.373
An. albimanus	Ivermectin	56% (56)	cχ² = 11.3 p < 0.001	4.7 ± 8.1	T = 1.5 df = 17 p = 0.143	95% (57)	cχ² = 0.9 p = 0.332	25.2 ± 7.2	T = 0.2 df = 4 p = 0.864
An. albimanus	Control	89% (52)	cχ² = 11.3 p < 0.001	12.8 ± 13.2	T = 1.5 df = 17 p = 0.143	85% (48)	cχ² = 0.9 p = 0.332	24.8 ± 10.0	T = 0.2 df = 4 p = 0.864

Mice received subcutaneous injections of either ivermectin (600 mg/kg BW) or saline (control group). Three mice were used for each treatment. Cohorts of age-matched mosquitoes (n = sample size) were blood-fed 1 day after injections and 3 days after injections

ISSN: 1475-2875