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Table 1 Crude extracts preparation yields and activity parameters

From: Potent antiplasmodial extracts and fractions from Terminalia mantaly and Terminalia superba

Plant

Part

Solvent

Extract code

Extraction yield (%)

IC50 ± SD (µg/mL)

RI

CC50 (µg/mL)

Selectivity Index

PfINDO

Pf3D7

PfINDO

Pf3D7

T. mantaly

Leaf

Water

Tmlw

35.50

2.09 ± 0.06

2.66 ± 0.31

0.79

> 200

> 95.69

> 75.19

Methanol

Tmlm

19.54

2.69 ± 0.04

2.61 ± 0.43

1.03

> 200

> 74.35

> 76.63

Stem bark

Water

Tmsbw

19.93

0.26 ± 0.02

1.03 ± 0.04

0.25

> 200

> 769.23

> 194.17

Methanol

Tmsbm

19.32

3.63 ± 0.50

2.91 ± 0.12

1.25

> 200

> 55.10

> 68.73

Root

Water

Tmrw

07.45

> 25

> 25

–

–

–

–

Methanol

Tmrm

09.01

7.01 ± 0.82

5.04 ± 0.68

1.39

> 200

> 28.53

> 39.68

T. superba

Leaf

Water

Tslw

17.18

0.57 ± 0.06

1.26 ± 0.12

0.45

> 200

> 350.88

> 158.73

Methanol

Tslm

12.07

3.38 ± 0.54

2.13 ± 0.13

1.59

> 200

> 59.17

> 93.90

Stem bark

Water

Tssbw

14.15

3.70 ± 0.03

1.42 ± 0.09

2.61

> 200

> 54.05

> 140.85

Methanol

Tssbm

10.35

2.68 ± 0.20

1.85 ± 0.13

1.44

> 200

> 74.63

> 108.11

Root

Water

Tsrw

04.54

18.88 ± 0.14

16.43 ± 0.14

1.15

–

–

–

Methanol

Tsrm

02.27

2.38 ± 0.08

2.28 ± 0.20

1.04

> 200

> 84.03

> 87.72

Reference drug

Chloroquine (µM)

–

0.40 ± 0.00

0.04 ± 0.01

10.00

–

–

–

  1. Activity data are presented as means of triplicate experiments
  2. IC50: 50% inhibitory concentration; CC50: 50% cell cytotoxic concentration, cytotoxicity was tested against HEK239T cells; SD: standard deviation from triplicate experiments; RI: resistance index; resistance index was calculated as the ratio of IC50 PfINDOresistant/IC50Pf3D7sensitive; SI: selectivity index; Tm: Terminalia mantaly; Ts: Terminalia superba; l: leaf; sb: stem bark; r: root; w: water; m: methanol