From: Potent antiplasmodial extracts and fractions from Terminalia mantaly and Terminalia superba
Plant | Crude extract | Solvent | Fraction code | Fraction yield (%) | IC50 ± SD (µg/mL) | RI | CC50 (µg/mL) | Selectivity index | ||
---|---|---|---|---|---|---|---|---|---|---|
PfINDO | Pf3D7 | PfINDO | Pf3D7 | |||||||
T. mantaly | Tmlw | Hexane | TmlwH | 0 | – | – | – | – | – | – |
Chl | TmlwChl | 20.78 | 0.36 ± 0.01 | 0.96 ± 0.01 | 0.37 | > 200 | > 555.55 | > 208.33 | ||
EA | TmlwEA | 2.54 | 6.74 ± 0.49 | 6.88 ± 0.58 | 0.98 | > 200 | > 29.67 | > 29.07 | ||
– | TmlwR3 | 43.79 | > 25 | > 25 | – | – | – | – | ||
Tmsbw | Hexane | TmsbwH | 0.16 | 4.50 ± 0.24 | 4.40 ± 0.27 | 1.02 | > 200 | > 44.44 | > 45.45 | |
Chl | TmsbwChl | 0.67 | 0.56 ± 0.05 | 1.12 ± 0.07 | 0.5 | > 200 | > 357.14 | > 178.57 | ||
EA | TmsbwEA | 1.26 | 0.68 ± 0.14 | 1.35 ± 0.42 | 0.5 | > 200 | > 294.11 | > 148.15 | ||
– | TmsbwR3 | 31.35 | 2.80 ± 0.21 | 2.44 ± 0.16 | 1.15 | > 200 | > 71.43 | > 8.97 | ||
T. superba | Tslw | Hexane | TslwH | 0.7 | 14.09 ± 1.88 | 6.99 ± 0.68 | 2.02 | 126.03 | > 14.19 | > 28.61 |
Chl | TslwChl | 4.74 | > 25 | > 25 | – | – | – | – | ||
EA | TslwEA | 4.47 | 6.89 ± 0.94 | 7.06 ± 0.76 | 0.97 | > 200 | > 29.03 | > 28.33 | ||
– | TslwR3 | 61.9 | > 25 | > 25 | – | – | – | – | ||
Tsrm | Hexane | TsrmH | 19.36 | > 25 | > 25 | – | – | – | – | |
Chl | TsrmChl | 5.54 | 2.26 ± 0.09 | 4.93 ± 0.73 | 0.46 | > 200 | > 88.49 | > 40.57 | ||
EA | TsrmEA | 6.18 | 1.82 ± 0.04 | 1.65 ± 0.24 | 1.1 | > 200 | > 109.89 | > 121.21 | ||
– | TsrmR3 | 63.82 | 5.22 ± 0.26 | 4.70 ± 1.47 | 1.11 | > 200 | > 38.31 | > 42.55 | ||
Reference drug | Chloroquine (µM) | – | 0.40 ± 0.00 | 0.04 ± 0.00 | 10 | – | – | – |