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Table 2 Yields of crude extracts fractionation and activity parameters

From: Potent antiplasmodial extracts and fractions from Terminalia mantaly and Terminalia superba

Plant

Crude extract

Solvent

Fraction code

Fraction yield (%)

IC50 ± SD (µg/mL)

RI

CC50 (µg/mL)

Selectivity index

PfINDO

Pf3D7

PfINDO

Pf3D7

T. mantaly

Tmlw

Hexane

TmlwH

0

–

–

–

–

–

–

Chl

TmlwChl

20.78

0.36 ± 0.01

0.96 ± 0.01

0.37

> 200

> 555.55

> 208.33

EA

TmlwEA

2.54

6.74 ± 0.49

6.88 ± 0.58

0.98

> 200

> 29.67

> 29.07

–

TmlwR3

43.79

> 25

> 25

–

–

–

–

Tmsbw

Hexane

TmsbwH

0.16

4.50 ± 0.24

4.40 ± 0.27

1.02

> 200

> 44.44

> 45.45

Chl

TmsbwChl

0.67

0.56 ± 0.05

1.12 ± 0.07

0.5

> 200

> 357.14

> 178.57

EA

TmsbwEA

1.26

0.68 ± 0.14

1.35 ± 0.42

0.5

> 200

> 294.11

> 148.15

–

TmsbwR3

31.35

2.80 ± 0.21

2.44 ± 0.16

1.15

> 200

> 71.43

> 8.97

T. superba

Tslw

Hexane

TslwH

0.7

14.09 ± 1.88

6.99 ± 0.68

2.02

126.03

> 14.19

> 28.61

Chl

TslwChl

4.74

> 25

> 25

–

–

–

–

EA

TslwEA

4.47

6.89 ± 0.94

7.06 ± 0.76

0.97

> 200

> 29.03

> 28.33

–

TslwR3

61.9

> 25

> 25

–

–

–

–

Tsrm

Hexane

TsrmH

19.36

> 25

> 25

–

–

–

–

Chl

TsrmChl

5.54

2.26 ± 0.09

4.93 ± 0.73

0.46

> 200

> 88.49

> 40.57

EA

TsrmEA

6.18

1.82 ± 0.04

1.65 ± 0.24

1.1

> 200

> 109.89

> 121.21

–

TsrmR3

63.82

5.22 ± 0.26

4.70 ± 1.47

1.11

> 200

> 38.31

> 42.55

Reference drug

Chloroquine (µM)

–

0.40 ± 0.00

0.04 ± 0.00

10

–

–

–

  1. Activity data are presented as means of triplicate experiments
  2. IC50: 50% inhibitory concentration; CC50: 50% cell cytotoxic concentration, cytotoxicity was tested against HEK239T cells; SD: standard deviation from triplicate experiments; RI: resistance index; resistance index was calculated as the ratio of IC50 PfINDOresistant/IC50Pf3D7sensitive; SI: selectivity index; Tm: Terminalia mantaly; Ts: Terminalia superba; Tmlw: Terminalia mantaly leaf water extract; Tmsbw: Terminalia mantaly stem bark water extract; Tslw: Terminalia superba leaf water extract; Tsrm: Terminalia superba root methanol extract; R3: final residue; H: hexane; Chl: chloroform; EA: ethyl acetate