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Table 1 Comparative inhibitory activities of Proveblue and primaquine on Plasmodium yoelii, Plasmodium falciparum and Plasmodium cynomolgi

From: Differential activity of methylene blue against erythrocytic and hepatic stages of Plasmodium

Drugs Methylene blue Primaquine
Parasites IC50 (µM) TI Size reduction at 11 µM (%) IC50 (µM) TI Size reduction at 11 µM (%)
P. yoelii (MH) >  100 1 10 0.64 ± 0.1a 110a ND
P. falciparum (HH) >  100 1 10 0.6 ± 0.06 66.5 100
P. cynomolgi (SH) >  100 1 10 2.72 ± 0.34 14.22 70
  1. MH mouse hepatocytes; HH human hepatocytes; SH simian hepatocytes; TI therapeutic index: TC50/IC50, ND not determined
  2. a[51]