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Table 1 Antiplasmodial activity and in vitro cytotoxicity values of the ethanolic extracts from P. latifolia and P. huberi

From: Anti-plasmodial effect of plant extracts from Picrolemma huberi and Picramnia latifolia

Code

Description

Activity

Cytotoxicity

 

IC50 FCR3 ± SD

IC50 3D7 ± SD

CC50 ± SD

SI

P. latifolia

Bark/leaves. Extraction by percolation with ethanol

7.6 ± 6.3

7.0 ± 0.83

146.6 ± 19.6

19.4

Bark/petiole. Extraction by percolation with ethanol

1.3 ± 0.09

1.21 ± 0.19

3.5 ± 0.48

2.9

P. huberi

Leaves/petiole/rachis. Extraction with hexane

39.3 ± 9.3

156.9 ± 12.7

142.5 ± 31.7

1.2

Leaves. Extraction with hexane

19.2 ± 0.2

51.8 ± 4.8

143.7 ± 36.0

4

Petiole/rachis. Extraction with hexane

16.5 ± 0.01

19.0 ± 2.5

53.7 ± 6.7

3

Petiole/rachis. Degreasing with hexane; extraction with ethanol/water (90:10).

0.2 ± 0.04

0.33 ± 0.08

5.8 ± 0.8

21.9

Cortex. Extraction with hexane.

14.4 ± 0.04

17.7 ± 2.3

21.8 ± 0.3

1.4

Cortex. Extraction with ethanol/water (90:10)

0.05 ± 0.0

0.09 ± 0.005

3.6 ± 0.3

51.4

Cortex. Degreasing with hexane; extraction with ethanol/water (90:10).

0.04 ± 0.01

0.08 ± 0.03

0.38 ± 0.0

6.3

P. huberi AMALFI

Cortex. Extraction with ethanol/water (90:10)

0.18 ± 0.02

CQ

0.064 ± 0.01

0.0057 ± 0.0

73.4 ± 11.4

FCCP

0.36 ± 0.04

  1. The data correspond to the inhibitory concentration 50 (IC50) ± standard deviation (DS), cytotoxic concentration 50 (CC50) ± standard deviation (SD) and calculated selectivity indexes (SI) of extracts from P. latifolia and P. Huberi Values are shown in µg/mL. Two or three independent trials were performed for each extract. Chloroquine (CQ) was used as a control for Plasmodium activity, FCCP (carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone) was used as a toxicity control