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Table 2 Hemolytic activity of extracts from P. latifolia and P. huberi plants in human erythrocytes

From: Anti-plasmodial effect of plant extracts from Picrolemma huberi and Picramnia latifolia

Sample

% hemolysis

Optical density (nm)

Tween 20 1%

100

4.28

DMSO 10%

0

0.2

Isoosmotic buffer

0

0.17

P. huberi (0.5 µg/mL) (10× IC50)a

0.43

0.19

P. latifolia (10 µg/mL) (8.5× IC50)b

1.35

0.21

  1. The data correspond to the percentage of hemolysis in human A+ erythrocytes. Two independent assays were performed for each ethanolic extract. Measurements were made after 1 h incubation of erythrocytes with ethanolic extracts. As control for total hemolysis (100%), 1% Tween 20 was used
  2. a10× IC50: ethanolic extract of P. huberi evaluated at a concentration 10 times higher than the IC50
  3. b8.5× IC50: ethanolic extract of P. latifolia evaluated at a concentration 8.5 times greater than IC50
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Malaria Journal

ISSN: 1475-2875

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