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Table 3 Parasitemias and averages of percent parasitemia inhibition in mice treated with the ethanolic extract of P. latifolia and with the ethanolic extract of P. huberi, during 3 days of follow-up

From: Anti-plasmodial effect of plant extracts from Picrolemma huberi and Picramnia latifolia

 

Average parasitemia

Average % inhibition

Treatment

Dose (mg/kg)

1 day POST-T ± SD

2 days POST-T ± SD

3 days POST-T ± SD

1 day POST-T ± SD

2 day POST-T ± SD

3 day POST-T ± SD

CLOROQUINE

10

0.5 ± 0.4

0.6 ± 0.5

0.5 ± 0.3

99.7 ± 1.5

99.3 ± 1.3

99.5 ± 0.8

C. officinalis

500

1.1 ± 1.0

1 ± 0.8

1.5 ± 1.8

84.0 ± 19.2

94.9 ± 4.5

96.3 ± 4.3

P. latifolia

1000

14.5 ± 5.0

24.3 ± 11.5

32.4 ± 4.2

52.1 ± 3.4

49.4 ± 26.2

51.3 ± 15.5

P. huberi

150

0.5 ± 0.4

1.4 ± 1.0

2.7 ± 2.1

93.0 ± 32.9

92.1 ± 42.6

93.0 ± 42.7

DMSO vehicle

–

20.2 ± 7.7

41.6 ± 12.3

67.6 ± 9.4

–

–

–

  1. The data correspond to the mean ± standard deviation (SD) of four or five mice treated for 4 days with the ethanolic extracts of the plants Picramnia latifolia and Picrolemma huberi. To calculate the % inhibition the vehicle DMSO was used as the control; additionally, chloroquine at 10 mg/kg body weight and an ethanol extract of Cinchona officinalis at 500 mg/kg were used as the parasitemia elimination controls
  2. POST-T post treatment
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Malaria Journal

ISSN: 1475-2875

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