Children with Ret + CM have greater parasite burden and suppressed total IgG in acute infection. a Receiver operator characteristics (ROC) curves generated from logistic regression models (PfHRP2, parasite genomes, PfHRP2 + parasite genomes) show that PfHRP2 and cell-free parasite genomes (cfPf DNA) differentiate children by case severity. Cell free parasite DNA is represented as P. falciparum genomes from cell free DNA qPCR, and PfHRP2 indicates plasma PfHRP2. b Median values of total IgG (mg/L) in acute infection and convalescence as measured by RID reveal suppression of total IgG in acute CM. P-values correspond to Wilcoxon’s rank-sum (unpaired) or signed rank (paired) tests. Healthy* data refers to sub-Saharan African children as described by Obiandu et al.