Convalescent Plasmodium falciparum-specific seroreactivity does not correlate with paediatric malaria severity or Plasmodium antigen exposure

Table 1 Clinical characteristics of Ret + CM and UM cases

Patient characteristic	Ret + CM (n = 25)	UM (n = 23)	P-value*
Age (yr), median [IQR]	3.5 [3, 4]	4 [2, 7]	0.29
Male, n (%)	15 (60.0)	17 (73.9)	0.31
Parasite smear score, median [IQR]	2 [2, 4]	4 [3, 4]	0.01
Pfhrp2 (ng/ml), median [IQR]	2580 [566, 10, 506]	216 [57, 484]	< 0.001
Cell free Pf DNA (genomes per μl), median [IQR]	904 [414, 1703]	60 [5, 471]	< 0.001
Hgb (g/dL), median [IQR]	7.4 [6.4, 9.1]	9.6 [7.7, 11.5]	0.01
Platelets (10³/μl), median [IQR]	66 [49, 88]	126 [64, 153]	0.03
Total WBC (10³/μl), median [IQR]	8.8 [6.5, 11.9]	7.8 [6.0, 9.4]	0.20
Var targets amplified^a (of n = 48), median [IQR]	21 [17, 24]	11 [7, 17]	< 0.001
ICAM-1 motif amplified^b, n (%)	10 (52.6%)	5 (21.7%)	0.04
Mortality, n (%)	0 (0)	0 (0)	1.00

IQR, interquartile range; * P-values correspond to Wilcoxon rank-sum or Chi squared test
^aN = X targets total, amplified using primers from Lavstsen et al. [19], Mkumbaye et al. [44]
^bMotif amplified using primers from Lennartz et al. [32]; Ret + CM n = 19

ISSN: 1475-2875