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Table 2 Reactivity to markers of prior malaria exposure and antigens of interest for all cases (UM and Ret + CM n = 48)

From: Convalescent Plasmodium falciparum-specific seroreactivity does not correlate with paediatric malaria severity or Plasmodium antigen exposure

Antigen/marker

Gene ID

Seroprevalence

Acute R

Convalescent R

P-value*

 

Plasmodium exported protein (GEXP18)

PF3D7_0402400

98 (47)

4.22 (3.69–4.74)

4.65 (4.28–5.02)

0.01

 

Exonuclease, putative

PF3D7_1106300

85 (41)

2.30 (1.85–2.76)

2.83 (2.39–3.27)

0.02

Markers of prior exposure

Erythrocyte membrane protein 1 (VAR)

PF3D7_0711700

100 (48)

4.51 (4.11–4.91)

4.73 (4.38–5.07)

0.13

Erythrocyte membrane protein 1 (VAR)

PF3D7_0800300

100 (48)

4.29 (3.83–4.74)

4.57 (4.17–4.97)

0.08

 

Heat shock protein 40, type II (HSP40)

PF3D7_0501100

100 (48)

3.29 (2.77–3.80)

4.58 (4.24–4.93)

< 0.0001

Helb et al. PNAS, [41]

Early transcribed membrane protein 4 (ETRAMP4)

PF3D7_0423700

100 (48)

3.71 (3.23–4.19)

4.18 (3.83–4.53)

0.02

Acyl-coA synthetase (ACS5)

PF3D7_0731600

79 (38)

2.36 (1.83–2.88)

2.85 (2.30–3.41)

0.01

 

PF70 protein (PF70)

PF3D7_1002100

100 (48)

5.12 (4.77–5.47)

5.69 (5.45–5.93)

0.01

 

Circumsporozoite protein (CSP)

PF3D7_0304600

44 (21)

0.95 (0.72–1.18)

0.99 (0.79–1.18)

0.67

Vaccine candidates and antigens of interest

Apical membrane antigen 1 (AMA1)

PF3D7_1133400

98 (47)

3.31 (2.83–3.79)

3.60 (3.27–3.94)

0.12

Merozoite surface protein 1 (MSP1)

PF3D7_0930300

100 (48)

4.51 (3.97–5.05)

5.04 (4.67–5.40)

0.02

Merozoite surface protein 2 (MSP2)

PF3D7_0206800

98 (47)

4.01 (3.51–4.50)

4.29 (3.88–4.69)

0.12

Erythrocyte binding antigen-175 (EBA175)

PF3D7_0731500

92 (44)

2.40 (1.96–2.84)

3.03 (2.64–3.41)

0.003

 

Glutamate-rich protein (GLURP)

PF3D7_1035300

88 (42)

2.47 (1.98–2.96)

2.53 (2.06–3.00)

0.70

 

Liver stage antigen 1 (LSA1)

PF3D7_1036400

100 (48)

3.70 (3.28–4.12)

4.00 (3.68–4.33)

0.08

 

Liver stage antigen 3 (LSA3)

PF3D7_0220000

100 (48)

4.45 (4.01–4.90)

5.50 (5.26–5.73)

< 0.0001

 
  1. Reactivity (R), mean (95% CI); * P-values correspond to Benjamini–Hochberg adjusted paired empirical Bayes t-test, Acute vs. Convalescent
  2. Seroprevalence, % (n) of cases with positive seroreactivity. R, seroreactivity where R >= 1 indicates a seropositive response
  3. Italic values indicate P < 0.05
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Malaria Journal

ISSN: 1475-2875

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