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Table 2 Reactivity to markers of prior malaria exposure and antigens of interest for all cases (UM and Ret + CM n = 48)

From: Convalescent Plasmodium falciparum-specific seroreactivity does not correlate with paediatric malaria severity or Plasmodium antigen exposure

Antigen/marker Gene ID Seroprevalence Acute R Convalescent R P-value*  
Plasmodium exported protein (GEXP18) PF3D7_0402400 98 (47) 4.22 (3.69–4.74) 4.65 (4.28–5.02) 0.01  
Exonuclease, putative PF3D7_1106300 85 (41) 2.30 (1.85–2.76) 2.83 (2.39–3.27) 0.02 Markers of prior exposure
Erythrocyte membrane protein 1 (VAR) PF3D7_0711700 100 (48) 4.51 (4.11–4.91) 4.73 (4.38–5.07) 0.13
Erythrocyte membrane protein 1 (VAR) PF3D7_0800300 100 (48) 4.29 (3.83–4.74) 4.57 (4.17–4.97) 0.08  
Heat shock protein 40, type II (HSP40) PF3D7_0501100 100 (48) 3.29 (2.77–3.80) 4.58 (4.24–4.93) <0.0001 Helb et al. PNAS, [41]
Early transcribed membrane protein 4 (ETRAMP4) PF3D7_0423700 100 (48) 3.71 (3.23–4.19) 4.18 (3.83–4.53) 0.02
Acyl-coA synthetase (ACS5) PF3D7_0731600 79 (38) 2.36 (1.83–2.88) 2.85 (2.30–3.41) 0.01  
PF70 protein (PF70) PF3D7_1002100 100 (48) 5.12 (4.77–5.47) 5.69 (5.45–5.93) 0.01  
Circumsporozoite protein (CSP) PF3D7_0304600 44 (21) 0.95 (0.72–1.18) 0.99 (0.79–1.18) 0.67 Vaccine candidates and antigens of interest
Apical membrane antigen 1 (AMA1) PF3D7_1133400 98 (47) 3.31 (2.83–3.79) 3.60 (3.27–3.94) 0.12
Merozoite surface protein 1 (MSP1) PF3D7_0930300 100 (48) 4.51 (3.97–5.05) 5.04 (4.67–5.40) 0.02
Merozoite surface protein 2 (MSP2) PF3D7_0206800 98 (47) 4.01 (3.51–4.50) 4.29 (3.88–4.69) 0.12
Erythrocyte binding antigen-175 (EBA175) PF3D7_0731500 92 (44) 2.40 (1.96–2.84) 3.03 (2.64–3.41) 0.003  
Glutamate-rich protein (GLURP) PF3D7_1035300 88 (42) 2.47 (1.98–2.96) 2.53 (2.06–3.00) 0.70  
Liver stage antigen 1 (LSA1) PF3D7_1036400 100 (48) 3.70 (3.28–4.12) 4.00 (3.68–4.33) 0.08  
Liver stage antigen 3 (LSA3) PF3D7_0220000 100 (48) 4.45 (4.01–4.90) 5.50 (5.26–5.73) <0.0001  
  1. Reactivity (R), mean (95% CI); * P-values correspond to Benjamini–Hochberg adjusted paired empirical Bayes t-test, Acute vs. Convalescent
  2. Seroprevalence, % (n) of cases with positive seroreactivity. R, seroreactivity where R >= 1 indicates a seropositive response
  3. Italic values indicate P < 0.05