Table 3 Reactivity to head structure/CIDR or ICAM-1 binding domain in exposed cases
Binding phenotype | Pf1000 array gene ID | Binding domain | Exposed (n of 48) | Acute responders, % (n) | New responders, % (n) | Non responders, % (n) |
|---|---|---|---|---|---|---|
EPCR | ||||||
PF3D7_0400400 | CIDRα1.1 | 26 | 4% (1) | 4% (1) | 92% (24) | |
PF3D7_1150400 | CIDRα1.4b | 2 | 0% (0) | 0% (0) | 100% (2) | |
PF3D7_0800300 | CIDRα1.6 | 9 | 22% (2) | 22% (2) | 56% (5) | |
PF3D7_0425800 | CIDRα1.6b | 9 | 11% (1) | 0% (0) | 89% (8) | |
ICAM-1a | ||||||
PF3D7_1150400 | DBLβ3 | 25 | 28% (7) | 4% (1) | 68% (17) | |
PF3D7_0425800 | DBLβ3 | 25 | 36% (9) | 4% (1) | 60% (15) | |
Rosetting | ||||||
PF3D7_1300300 | CIDRδ1 | 12 | 67% (8) | 8% (1) | 25% (3) | |
PF3D7_0800200 | CIDRδ2 | 12 | 0% (0) | 25% (3) | 75% (9) | |
CD36 | ||||||
PF3D7_1200100 | CIDRα2.2 | 8 | 50% (4) | 12% (1) | 38% (3) | |
PF3D7_0200100 | CIDRα2.2 | 8 | 0% (0) | 0% (0) | 100% (8) | |
PF3D7_0809100 | CIDRα2.2 | 8 | 50% (4) | 0% (0) | 50% (4) | |
PF3D7_0200100 | CIDRα2.2 | 8 | 88% (7) | 12% (1) | 0% (0) | |
PF3D7_1255200 | CIDRα2.3 | 32 | 12% (4) | 6% (2) | 82% (26) | |
PF3D7_1041300 | CIDRα2.7 | 32 | 72% (23) | 12% (4) | 16% (5) | |
PF3D7_0808700 | CIDRα3.1 | 14 | 50% (7) | 29% (4) | 21% (3) | |
PF3D7_1000100 | CIDRα3.1 | 14 | 50% (7) | 14% (2) | 36% (5) | |
PF3D7_0712900 | CIDRα3.1 | 14 | 0% (0) | 7% (1) | 93% (13) | |
PF3D7_1240600 | CIDRα3.1 | 14 | 7% (1) | 0% (0) | 93% (13) | |
PF3D7_0937800 | CIDRα3.1 | 14 | 64% (9) | 7% (1) | 29% (4) | |
PF3D7_0412900 | CIDRα3.1 | 14 | 7% (1) | 0% (0) | 93% (13) | |
PF3D7_0712600 | CIDRα3.1 | 14 | 36% (5) | 0% (0) | 64% (9) | |
PF3D7_0712000 | CIDRα3.1 | 14 | 0% (0) | 7% (1) | 93% (13) | |
PF3D7_0833500 | CIDRα3.1 | 14 | 43% (6) | 14% (2) | 43% (6) | |
PF3D7_0632500 | CIDRα3.2 | 14 | 64% (9) | 21% (3) | 14% (2) | |
PF3D7_0420700 | CIDRα3.2 | 14 | 0% (0) | 7% (1) | 93% (13) | |
PF3D7_0420900 | CIDRα3.2 | 14 | 0% (0) | 0% (0) | 100% (14) | |
PF3D7_0711700 | CIDRα3.2 | 14 | 0% (0) | 0% (0) | 100% (14) | |
PF3D7_0412700 | CIDRα3.2 | 14 | 14% (2) | 7% (1) | 79% (11) | |
PF3D7_0808600 | CIDRα3.2 | 14 | 14% (2) | 7% (1) | 79% (11) | |
PF3D7_1100100 | CIDRα3.2 | 14 | 29% (4) | 21% (3) | 50% (7) | |
PF3D7_0421300 | CIDRα3.4 | 26 | 15% (4) | 0% (0) | 85% (22) | |
PF3D7_0900100 | CIDRα3.4 | 26 | 35% (9) | 15% (4) | 50% (13) | |
PF3D7_1219300 | CIDRα3.4 | 26 | 15% (4) | 8% (2) | 77% (20) | |
PF3D7_1373500 | CIDRα3.4 | 26 | 11% (3) | 4% (1) | 85% (22) | |
PF3D7_0733000 | CIDRα3.4 | 26 | 0% (0) | 4% (1) | 96% (25) | |
PF3D7_0223500 | CIDRα3.4 | 26 | 50% (13) | 15% (4) | 35% (9) | |
PF3D7_1240400 | CIDRα3.4 | 26 | 50% (13) | 8% (2) | 42% (11) | |