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Table 3 Reactivity to head structure/CIDR or ICAM-1 binding domain in exposed cases

From: Convalescent Plasmodium falciparum-specific seroreactivity does not correlate with paediatric malaria severity or Plasmodium antigen exposure

Binding phenotype Pf1000 array gene ID Binding domain Exposed (n of 48) Acute responders, % (n) New responders, % (n) Non responders, % (n)
EPCR
  PF3D7_0400400 CIDRα1.1 26 4% (1) 4% (1) 92% (24)
  PF3D7_1150400 CIDRα1.4b 2 0% (0) 0% (0) 100% (2)
  PF3D7_0800300 CIDRα1.6 9 22% (2) 22% (2) 56% (5)
  PF3D7_0425800 CIDRα1.6b 9 11% (1) 0% (0) 89% (8)
ICAM-1a
  PF3D7_1150400 DBLβ3 25 28% (7) 4% (1) 68% (17)
  PF3D7_0425800 DBLβ3 25 36% (9) 4% (1) 60% (15)
Rosetting
  PF3D7_1300300 CIDRδ1 12 67% (8) 8% (1) 25% (3)
  PF3D7_0800200 CIDRδ2 12 0% (0) 25% (3) 75% (9)
CD36
  PF3D7_1200100 CIDRα2.2 8 50% (4) 12% (1) 38% (3)
  PF3D7_0200100 CIDRα2.2 8 0% (0) 0% (0) 100% (8)
  PF3D7_0809100 CIDRα2.2 8 50% (4) 0% (0) 50% (4)
  PF3D7_0200100 CIDRα2.2 8 88% (7) 12% (1) 0% (0)
  PF3D7_1255200 CIDRα2.3 32 12% (4) 6% (2) 82% (26)
  PF3D7_1041300 CIDRα2.7 32 72% (23) 12% (4) 16% (5)
  PF3D7_0808700 CIDRα3.1 14 50% (7) 29% (4) 21% (3)
  PF3D7_1000100 CIDRα3.1 14 50% (7) 14% (2) 36% (5)
  PF3D7_0712900 CIDRα3.1 14 0% (0) 7% (1) 93% (13)
  PF3D7_1240600 CIDRα3.1 14 7% (1) 0% (0) 93% (13)
  PF3D7_0937800 CIDRα3.1 14 64% (9) 7% (1) 29% (4)
  PF3D7_0412900 CIDRα3.1 14 7% (1) 0% (0) 93% (13)
  PF3D7_0712600 CIDRα3.1 14 36% (5) 0% (0) 64% (9)
  PF3D7_0712000 CIDRα3.1 14 0% (0) 7% (1) 93% (13)
  PF3D7_0833500 CIDRα3.1 14 43% (6) 14% (2) 43% (6)
  PF3D7_0632500 CIDRα3.2 14 64% (9) 21% (3) 14% (2)
  PF3D7_0420700 CIDRα3.2 14 0% (0) 7% (1) 93% (13)
  PF3D7_0420900 CIDRα3.2 14 0% (0) 0% (0) 100% (14)
  PF3D7_0711700 CIDRα3.2 14 0% (0) 0% (0) 100% (14)
  PF3D7_0412700 CIDRα3.2 14 14% (2) 7% (1) 79% (11)
  PF3D7_0808600 CIDRα3.2 14 14% (2) 7% (1) 79% (11)
  PF3D7_1100100 CIDRα3.2 14 29% (4) 21% (3) 50% (7)
  PF3D7_0421300 CIDRα3.4 26 15% (4) 0% (0) 85% (22)
  PF3D7_0900100 CIDRα3.4 26 35% (9) 15% (4) 50% (13)
  PF3D7_1219300 CIDRα3.4 26 15% (4) 8% (2) 77% (20)
  PF3D7_1373500 CIDRα3.4 26 11% (3) 4% (1) 85% (22)
  PF3D7_0733000 CIDRα3.4 26 0% (0) 4% (1) 96% (25)
  PF3D7_0223500 CIDRα3.4 26 50% (13) 15% (4) 35% (9)
  PF3D7_1240400 CIDRα3.4 26 50% (13) 8% (2) 42% (11)
  1. Exposed, domain amplified in acute infection
  2. Responders: Acute, reactive in acute infection; New, reactive only in convalescence; Non, not reactive
  3. aExposure status available for n = 42
  4. bHead structure/CIDR domains followed by ICAM-1 DBLβ3 domain (CIDRα1-DBLβ)