Fig. 4

Changes in abundance of miRNA of interest in MV, MV-free plasma and brain tissue. Dot plots show the expression levels of miR-146a, miR-193b, miR-205, miR-215, miR-467a, miR-150, and miR-486 measured for MV, MV-free plasma, and brains from NI, NCM, and CM conditions, expressed as normalized values as compared to the expression of a panel of control miRNA in each case. The results are presented as follows: significant changes in MV – miR-146a and miR-193b, significant changes in the brain—miR-205, miR-215, and miR-467a, no significant changes—miR-150 and miR-486. miR-146a and miR-467a also showed significant changes in the MV-free plasma. The horizontal line denotes the mean value, and the error bars denote SEM. A nonparametric Kruskal–Wallis test was carried out. If the Kruskal–Wallis test was significant, post hoc tests—Dunn’s multiple comparisons test—were carried out. The results of these are denoted as * = 0.05–0.01, ** = 0.01–0.0001, *** ≤ 0.0001