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Table 2 The percentage of resistant phenotypes of P. falciparum isolated from along the Thai–Cambodia border collected before 2009 and from 2009 to2016

From: Phenotypic and genotypic characterization of Thai isolates of Plasmodium falciparum after an artemisinin resistance containment project

Drug

Total% (n)

Before 2009% (n)

2009–2016% (n)

p value

CQ

99.0 (100/101)

98.0 (49/50)

100 (51/51)

0.500

QN

0 (0/101)

0 (0/50)

0 (0/51)

–

MQ

39.6 (40/101)

22.0 (11/50)

56.9 (29/51)

< 0.001

ARS

0 (0/101)

0 (0/50)

0 (0/51)

–

DHA

0 (0/95)

0 (0/44)

0 (0/51)

–

ATQ

0 (0/50)

–

0 (0/50)

–

  1. Significant differences of resistant phenotype between parasites collected before 2009 and from 2009 to 2016 determined using Fisher’s Exact test
  2. CQ resistance was defined as IC50 ≥ 25 nM, QN resistance was defined as IC50 > 800 nM, MQ resistance was defined as IC50 > 30 nM, ARS resistance was defined as IC50 > 10.5 nM, DHA resistance was defined as IC50 > 10.5 nM and ATQ resistance was defined as IC50 > 1900 nM
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