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Table 5 Correlation of antimalarial drug sensitivities and pfmdr1 and K13 gene of P. falciparum collected along the Thai–Cambodian border

From: Phenotypic and genotypic characterization of Thai isolates of Plasmodium falciparum after an artemisinin resistance containment project

Genotype

IC50 (nM)

CQ

QN

MQ

PPQ

ARN

DHA

pfmdr1

 86

  N86

107.1 ± 52.5

229.4 ± 130.6*

29.5 ± 26.0*

21.2 ± 10.9

3.0 ± 1.8

2.4 ± 1.1

  86Y

67.8 ± 41.9

92.3 ± 71.0

7.6 ± 3.9

19.1 ± 7.7

2.5 ± 0.9

3.0 ± 1.8

 184

  Y184

74.7 ± 38.3

104.1 ± 67.7*

12.6 ± 11.6*

19.9 ± 6.4

2.6 ± 1.1

2.9 ± 1.5

  184F

108.2 ± 53.1

232.7 ± 131.2

29.6 ± 26.3

21.2 ± 11.1

3.0 ± 1.8

2.4 ± 1.1

 1034

  S1034

103.3 ± 54.7

218.1 ± 135.8

30.6 ± 26.1*

21.6 ± 10.9

3.0 ± 1.8

2.4 ± 1.1

  1034C

116.2 ± 33.1

231.2 ± 103.8

8.4 ± 7.8

10.9 ± 7.8

2.6 ± 1.5

2.6 ± 1.5

 1042

  N1042

104.2 ± 55.8

221.2 ± 133.0

31.9 ± 26.4*

22.2 ± 10.8*

3.0 ± 1.8

2.4 ± 1.1

  1042D

107.8 ± 35.0

260.5 ± 122.2

8.7 ± 6.2

14.4 ± 7.2

2.8 ± 1.6

2.7 ± 1.3

 Copy no.

  ≤ 1

104.8 ± 49.4

227.8 ± 140.0

33.9 ± 30.2*

18.8 ± 6.3

3.2 ± 1.7

2.5 ± 1.2

  > 1

105.9 ± 56.4

214.3 ± 123.0

21.9 ± 18.0

22.9 ± 13.2

2.9 ± 1.8

2.5 ± 1.1

K13

 539

  R539

106.3 ± 54.7

212.0 ± 125.7

26.7 ± 24.5

21.6 ± 10.9

2.9 ± 1.7

2.5 ± 1.2

  539T

96.2 ± 38.9

272.7 ± 189.2

42.1 ± 34.5

16.4 ± 10.0

4.3 ± 1.8*

2.0 ± 0.7

 580

  C580

97.6 ± 39.9

216.5 ± 128.8

27.3 ± 26.5

18.1 ± 8.7

2.7 ± 1.4

2.6 ± 1.2

  580Y

118.9 ± 69.6

219.3 ± 140.8

29.6 ± 24.6

25.5 ± 11.9*

3.4 ± 2.1

2.3 ± 1.1

  1. * Represents a significant difference of mean IC50 ± SD at p < 0.05, Independent t test