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Table 5 Correlation of antimalarial drug sensitivities and pfmdr1 and K13 gene of P. falciparum collected along the Thai–Cambodian border

From: Phenotypic and genotypic characterization of Thai isolates of Plasmodium falciparum after an artemisinin resistance containment project

Genotype IC50 (nM)
CQ QN MQ PPQ ARN DHA
pfmdr1
 86
  N86 107.1 ± 52.5 229.4 ± 130.6* 29.5 ± 26.0* 21.2 ± 10.9 3.0 ± 1.8 2.4 ± 1.1
  86Y 67.8 ± 41.9 92.3 ± 71.0 7.6 ± 3.9 19.1 ± 7.7 2.5 ± 0.9 3.0 ± 1.8
 184
  Y184 74.7 ± 38.3 104.1 ± 67.7* 12.6 ± 11.6* 19.9 ± 6.4 2.6 ± 1.1 2.9 ± 1.5
  184F 108.2 ± 53.1 232.7 ± 131.2 29.6 ± 26.3 21.2 ± 11.1 3.0 ± 1.8 2.4 ± 1.1
 1034
  S1034 103.3 ± 54.7 218.1 ± 135.8 30.6 ± 26.1* 21.6 ± 10.9 3.0 ± 1.8 2.4 ± 1.1
  1034C 116.2 ± 33.1 231.2 ± 103.8 8.4 ± 7.8 10.9 ± 7.8 2.6 ± 1.5 2.6 ± 1.5
 1042
  N1042 104.2 ± 55.8 221.2 ± 133.0 31.9 ± 26.4* 22.2 ± 10.8* 3.0 ± 1.8 2.4 ± 1.1
  1042D 107.8 ± 35.0 260.5 ± 122.2 8.7 ± 6.2 14.4 ± 7.2 2.8 ± 1.6 2.7 ± 1.3
 Copy no.
  ≤ 1 104.8 ± 49.4 227.8 ± 140.0 33.9 ± 30.2* 18.8 ± 6.3 3.2 ± 1.7 2.5 ± 1.2
  > 1 105.9 ± 56.4 214.3 ± 123.0 21.9 ± 18.0 22.9 ± 13.2 2.9 ± 1.8 2.5 ± 1.1
K13
 539
  R539 106.3 ± 54.7 212.0 ± 125.7 26.7 ± 24.5 21.6 ± 10.9 2.9 ± 1.7 2.5 ± 1.2
  539T 96.2 ± 38.9 272.7 ± 189.2 42.1 ± 34.5 16.4 ± 10.0 4.3 ± 1.8* 2.0 ± 0.7
 580
  C580 97.6 ± 39.9 216.5 ± 128.8 27.3 ± 26.5 18.1 ± 8.7 2.7 ± 1.4 2.6 ± 1.2
  580Y 118.9 ± 69.6 219.3 ± 140.8 29.6 ± 24.6 25.5 ± 11.9* 3.4 ± 2.1 2.3 ± 1.1
  1. * Represents a significant difference of mean IC50 ± SD at p < 0.05, Independent t test