Genotype | IC50 (nM) | |||||
---|---|---|---|---|---|---|
CQ | QN | MQ | PPQ | ARN | DHA | |
pfmdr1 | ||||||
 86 | ||||||
  N86 | 107.1 ± 52.5 | 229.4 ± 130.6* | 29.5 ± 26.0* | 21.2 ± 10.9 | 3.0 ± 1.8 | 2.4 ± 1.1 |
  86Y | 67.8 ± 41.9 | 92.3 ± 71.0 | 7.6 ± 3.9 | 19.1 ± 7.7 | 2.5 ± 0.9 | 3.0 ± 1.8 |
 184 | ||||||
  Y184 | 74.7 ± 38.3 | 104.1 ± 67.7* | 12.6 ± 11.6* | 19.9 ± 6.4 | 2.6 ± 1.1 | 2.9 ± 1.5 |
  184F | 108.2 ± 53.1 | 232.7 ± 131.2 | 29.6 ± 26.3 | 21.2 ± 11.1 | 3.0 ± 1.8 | 2.4 ± 1.1 |
 1034 | ||||||
  S1034 | 103.3 ± 54.7 | 218.1 ± 135.8 | 30.6 ± 26.1* | 21.6 ± 10.9 | 3.0 ± 1.8 | 2.4 ± 1.1 |
  1034C | 116.2 ± 33.1 | 231.2 ± 103.8 | 8.4 ± 7.8 | 10.9 ± 7.8 | 2.6 ± 1.5 | 2.6 ± 1.5 |
 1042 | ||||||
  N1042 | 104.2 ± 55.8 | 221.2 ± 133.0 | 31.9 ± 26.4* | 22.2 ± 10.8* | 3.0 ± 1.8 | 2.4 ± 1.1 |
  1042D | 107.8 ± 35.0 | 260.5 ± 122.2 | 8.7 ± 6.2 | 14.4 ± 7.2 | 2.8 ± 1.6 | 2.7 ± 1.3 |
 Copy no. | ||||||
  ≤ 1 | 104.8 ± 49.4 | 227.8 ± 140.0 | 33.9 ± 30.2* | 18.8 ± 6.3 | 3.2 ± 1.7 | 2.5 ± 1.2 |
  > 1 | 105.9 ± 56.4 | 214.3 ± 123.0 | 21.9 ± 18.0 | 22.9 ± 13.2 | 2.9 ± 1.8 | 2.5 ± 1.1 |
K13 | ||||||
 539 | ||||||
  R539 | 106.3 ± 54.7 | 212.0 ± 125.7 | 26.7 ± 24.5 | 21.6 ± 10.9 | 2.9 ± 1.7 | 2.5 ± 1.2 |
  539T | 96.2 ± 38.9 | 272.7 ± 189.2 | 42.1 ± 34.5 | 16.4 ± 10.0 | 4.3 ± 1.8* | 2.0 ± 0.7 |
 580 | ||||||
  C580 | 97.6 ± 39.9 | 216.5 ± 128.8 | 27.3 ± 26.5 | 18.1 ± 8.7 | 2.7 ± 1.4 | 2.6 ± 1.2 |
  580Y | 118.9 ± 69.6 | 219.3 ± 140.8 | 29.6 ± 24.6 | 25.5 ± 11.9* | 3.4 ± 2.1 | 2.3 ± 1.1 |