Table 6 In vitro antimalarial sensitivities of different haplotype subgroups of P. falciparum
Drug IC50 (nM) | Haplotypes | p value | |||||
|---|---|---|---|---|---|---|---|
I (n = 7) | II (n = 26) | III (n = 34) | IV (n = 8) | V (n = 5) | VI (n = 9) | ||
CQ | 67.8 ± 41.9 | 93.8 ± 37.9 | 118.8 ± 71.0 | 99.6 ± 40.3 | 97.6 ± 43.6 | 120.4 ± 30.9 | 0.188 |
QN | 92.3 ± 71.0 | 207.6 ± 100.7 | 222.2 ± 142.5 | 290.7 ± 193.9 | 281.3 ± 155.4 | 259.5 ± 98.7 | 0.053 |
MQ | 7.6 ± 3.9 | 36.8 ± 27.0 | 31.1 ± 25.6 | 43.5 ± 36.6 | 12.7 ± 7.6 | 6.1 ± 3.1 | 0.002 |
PPQ | 19.1 ± 7.7 | 17.2 ± 7.3 | 25.6 ± 12.3 | 16.8 ± 7.4 | 11.0 ± 4.3 | 16.3 ± 8.0 | 0.013 |
ARS | 2.5 ± 0.9 | 2.3 ± 1.0 | 3.4 ± 2.2 | 4.2 ± 1.9 | 3.1 ± 1.7 | 1.5 ± 0.5 | 0.063 |
DHA | 3.0 ± 1.8 | 2.6 ± 1.1 | 2.3 ± 1.2 | 2.1 ± 0.6 | 2.6 ± 0.8 | 2.8 ± 1.6 | 0.588 |