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Table 6 In vitro antimalarial sensitivities of different haplotype subgroups of P. falciparum

From: Phenotypic and genotypic characterization of Thai isolates of Plasmodium falciparum after an artemisinin resistance containment project

Drug IC50 (nM) Haplotypes p value
I (n = 7) II (n = 26) III (n = 34) IV (n = 8) V (n = 5) VI (n = 9)
CQ 67.8 ± 41.9 93.8 ± 37.9 118.8 ± 71.0 99.6 ± 40.3 97.6 ± 43.6 120.4 ± 30.9 0.188
QN 92.3 ± 71.0 207.6 ± 100.7 222.2 ± 142.5 290.7 ± 193.9 281.3 ± 155.4 259.5 ± 98.7 0.053
MQ 7.6 ± 3.9 36.8 ± 27.0 31.1 ± 25.6 43.5 ± 36.6 12.7 ± 7.6 6.1 ± 3.1 0.002
PPQ 19.1 ± 7.7 17.2 ± 7.3 25.6 ± 12.3 16.8 ± 7.4 11.0 ± 4.3 16.3 ± 8.0 0.013
ARS 2.5 ± 0.9 2.3 ± 1.0 3.4 ± 2.2 4.2 ± 1.9 3.1 ± 1.7 1.5 ± 0.5 0.063
DHA 3.0 ± 1.8 2.6 ± 1.1 2.3 ± 1.2 2.1 ± 0.6 2.6 ± 0.8 2.8 ± 1.6 0.588
  1. Significant difference of mean IC50 was determined by One-way ANOVA