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Table 1 Description of outcomes of pregnancies by exposure

From: A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy

 

Live term

Live preterm

Miscarriage

Stillbirth

Termination

Atovaquone–proguanil (n = 10)

10a

0

0

0

0

Chloroquine (n = 6)

1

3b

1

1

0

Mefloquine (n = 15)

13c,d

0

1

1

0

Unknown anti-malarial (n = 2)

0

1

1

0

0

No anti-malarials (n = 760)

632e

50

69

3

6

No drugs at all (n = 235)f

181

13

32

1

3

  1. aIncludes two pregnancies with additional anti-malarial exposures in addition to atovaquone–proguanil: one to doxycycline, another to both chloroquine and mefloquine
  2. bIncludes one pregnancy also exposed to artemether–lumefantrine and one pregnancy exposed to plaquenil (considered equivalent to CQ)
  3. cIncludes one pregnancy with chloroquine exposure
  4. dBirth defects reported in 2 infants: incomplete syndactyly and right branchial cleft anomaly, no surgical intervention needed for either
  5. eOverall rate of birth defects was 3.8% (29/760), and the defects were varied with the most common being cleft lip/palate 13.8% (4/29); 65.5% (19/29) of infants with birth defects required surgical intervention
  6. fFive pregnancies had unknown outcome. Overall rate of birth defects was 1.4% (4/280): congenital hydronephrosis, ambiguous genitalia, and 2 unspecified