Table 5 Univariate analysis: comparison of continuous clinical and EEG variables by outcome (neurological morbidity in survivors) (mean ± SD)
From: Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes
Country | Clinical or EEG variable | Alive and normal (N = 56) | Alive with sequelae (N = 44) | p value |
|---|---|---|---|---|
Uganda | Age (years) | 3.8 ± 1.7 | 3.8 ± 2.2 | 0.5312 |
Glucose (mg/dL) | 7.2 ± 3.3 | 6.4 ± 3.4 | 0.1376 | |
Parasitemia (parasites/µL) [geometric mean (coefficient of variation)] | 31,931.6 (23.3) | 31,434.9 (18.7) | 0.9755 | |
Lactate (mmol/L) | 4.6 ± 3.7 | 5.3 ± 4.2 | 0.4449 | |
Average voltage (µV) | 74.0 ± 32.1 | 63.6 ± 30.8 | 0.0723 | |
Maximum voltage (µV) | 213.8 ± 71.2 | 199.1 ± 70.3 | 0.3809 | |
Dominant frequency (Hz) | 2.0 ± 0.7 | 2.0 ± 0.6 | 0.9210 |
Country | Clinical or EEG variable | Alive and normal (N = 121) | Alive with sequelae (N = 16) | p value |
|---|---|---|---|---|
Malawi | Age (years) | 4.3 ± 2.3 | 3.5 ± 1.9 | |
Glucose (mg/dL) | 6.9 ± 2.9 | 8.3 ± 7.0 | 0.6468 | |
Parasitemia (parasites/µL) [geometric mean (coefficient of variation)] | 28,148.2 (27.4) | 73,486.0 (10.4) | 0.1988 | |
Lactate (mmol/L) | 7.0 ± 4.0 | 8.4 ± 4.8 | 0.3023 | |
Average voltage (µV) | 114.5 ± 54.2 | 91.5 ± 52.6 | 0.2178 | |
Maximum voltage (µV) | 217.4 ± 86.3 | 180.0 ± 103.1 | 0.1185 | |
Dominant frequency (Hz) | 2.4 ± 1.1 | 2.1 ± 1.3 | 0.1550 |
Country | Clinical or EEG variable | Alive and normal (N = 177) | Alive with sequelae (N = 60) | p value |
|---|---|---|---|---|
Uganda + Malawi | Age (years) | 4.2 ± 2.2 | 3.7 ± 2.1 | 0.0723 |
Glucose (mg/dL) | 7.0 ± 3.0 | 6.9 ± 4.7 | 0.1999 | |
Parasitemia (parasites/µL) [geometric mean (coefficient of variation)] | 29,312.6 (25.57) | 38,422.1 (16.66) | 0.4876 | |
Lactate (mmol/L) | 6.3 ± 4.0 | 6.1 ± 4.5 | 0.5321 | |
Average voltage (µV) | 101.9 ± 51.9 | 70.1 ± 38.4 | < 0.0001 | |
Maximum voltage (µV) | 216.3 ± 81.8 | 194.6 ± 78.5 | 0.0943 | |
Dominant frequency (Hz) | 2.3 ± 1.0 | 2.0 ± 0.8 | 0.0524 |