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Table 1 Genes expressed more or less than tenfold (p < 0.01) in the liver of vaccinated mice infected with P. chabaudi on day 4 p.i. (Vd4) in comparison to constitutive expression on day 0 p.i. (Vd0)

From: Gene expression of the liver of vaccination-protected mice in response to early patent infections of Plasmodium chabaudi blood-stage malaria

Gene Gene description RefSeq ID Vd4 vs. Vd0 p value Function (annotated according to
 Ahsp Alpha hemoglobin stabilizing protein NM_133245 48.18 0.0095 Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia
 Cldn13 Claudin 13 NM_020504 43.50 0.0070 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity
 Ermap Erythroblast membrane-associated protein NM_013848 21.59 0.0036 The protein encoded by this gene is a cell surface transmembrane protein that may act as an erythroid cell receptor, possibly as a mediator of cell adhesion
 Gata1 GATA binding protein 1 NM_008089 29.73 0.0015 Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development
 Gfi1b Growth factor independent 1B NM_008114 20.50 0.0092 Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages
 Kel Kell blood group NM_032540 65.89 0.0010 This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen
 Rhag Rhesus blood group-associated A glycoprotein NM_011269 17.37 0.0001 The protein encoded by this gene is erythrocyte-specific and is thought to be part of a membrane channel that transports ammonium and carbon dioxide across the blood cell membrane
 Slc4a1 Solute carrier family 4 NM_011403 11.74 0.0067 Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin
Cell cycle and mitosis
 Ccnb1 Cyclin B1 NM_172301 17.76 < 0.0001 The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF)
 Cdc25c Cell division cycle 25C NM_009860 12.41 0.0009 Cdc25 activates cdk complexes that drive the cell cycle. Cdc25 is involved in the DNA damage checkpoints and is known as a key mediator of cell cycle progression
 Ckap2 l Cytoskeleton associated protein 2-like NM_181589 10.72 0.0030 Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells
Innate immunity
 Abcg4 ATP-binding cassette, sub-family G (WHITE), member 4 NM_138955 26.79 0.0035 The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. May be involved in macrophage lipid homeostasis
 Ccl7 Chemokine (C-C motif) ligand 7 NM_013654 34.97 0.0013 Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils
 Socs1 Suppressor of cytokine signaling 1 NM_009896 11.32 0.0070 This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma
Treml2 Triggering receptor expressed on myeloid cells-like 2 NM_001033405 10.92 0.0001 Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation
 Cd163 CD163 antigen NM_053094 0.03 0.0018 The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage
 Gzmb Granzyme B NM_013542 35.66 0.0085 The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing
 Klrb1a Killer cell lectin-like receptor subfamily B member 1A NM_010737 10.43 0.0083 Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3
 Klrc3 Killer cell lectin-like receptor subfamily C, member 3 NM_021378 11.38 0.0002 KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain
 Klrd1 Killer cell lectin-like receptor, subfamily D, member 1 NM_010654 16.33 0.0067 Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells
 Ncr1 Natural cytotoxicity triggering receptor 1 NM_010746 16.97 0.0084 Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis
 Hist1h3g Histone cluster 1, H3g NM_145073 18.90 0.0075 Core component of nucleosome
 Htr7 5-Hydroxytryptamine (serotonin) receptor 7 NM_008315 12.53 < 0.0001 Serotonin 5-HT7 receptors are located primarily in the thalamus, hypothalamus and hippocampus. The function of these receptors includes the regulation of circadian rhythms, thermoregulation, learning and memory and smooth muscle relaxation
 Nxpe5 Neurexophilin and PC-esterase domain family, member 5 NM_001013773 22.61 0.0089 Unknown