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Table 2 Hepatic expression of genes up-regulated by more than tenfold (p < 0.01) at Vd4 and by 100% more than at Nd4

From: Gene expression of the liver of vaccination-protected mice in response to early patent infections of Plasmodium chabaudi blood-stage malaria

Gene Gene description RefSeq ID Vd4 vs. Vd0 p value Nd4 vs. Nd0 p value Function (annotated according to
 Bub1 Budding uninhibited by benzimidazoles 1 homolog NM_009772 20.11 0.0049 5.88 0.0021 Serine/threonine-protein kinase that performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment
 Espl1 Extra spindle poles-like 1 NM_001014976 12.35 0.0013 4.98 0.0020 Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase
 Mki67 Antigen identified by monoclonal antibody Ki 67 NM_001081117 13.08 0.0004 4.29 0.0014 Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly
 Mxd3 Max dimerization protein 3 NM_016662 10.52 0.0031 3.84 0.0066 This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription
 Ndc80 NDC80 homolog, kinetochore complex component NM_023294 11.19 0.0004 4.74 0.0005 Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity
 Nusap1 Nucleolar and spindle associated protein 1 NM_133851 14.19 0.0002 4.89 0.0005 NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization
 Plk1 Polo-like kinase 1 NM_011121 14.14 0.0035 4.13 0.0018 Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis
 Prc1 Protein regulator of cytokinesis 1 NM_145150 15.38 < 0.0001 4.28 0.0003 The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase
 Racgap1 Rac GTPase-activating protein 1 NM_001253809 12.67 0.0042 3.83 0.0003 Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis
 Ska1 Spindle and kinetochore associated complex subunit 1 NM_025581 23.19 0.0004 5.46 0.0039 Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation
 Ska3 Spindle and kinetochore associated complex subunit 3 NM_198605 15.24 0.0027 4.68 0.0013 This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis
 Ticrr TOPBP1-interacting checkpoint and replication regulator NM_029835 14.22 0.0008 4.66 0.0093 Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins
 Tpx2 TPX2, microtubule-associated protein homolog NM_028109 16.11 0.0032 4.28 0.0011 Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis
 Ube2c Ubiquitin-conjugating enzyme E2C NM_026785 12.49 < 0.0001 4.32 0.0010 Essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis
Cell cycle/cell signaling
 Klrb1f Killer cell lectin-like receptor subfamily B member 1F NM_153094 10.63 0.0005 5.32 0.0003 Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide
 Birc5 Baculoviral IAP repeat-containing 5 NM_009689 16.68 0.0005 3.47 0.0006 This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death
 Cd7 CD7 antigen NM_009854 13.52 0.0022 4.54 0.0005 Plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development
 Kif11 Kinesin family member 11 NM_010615 11.80 0.0065 3.62 0.0077 Motor protein required for establishing a bipolar spindle during mitosis
 Prr11 Proline rich 11 NM_175563 12.13 0.0001 4.52 0.0001 Plays a critical role in cell cycle progression
 Sapcd2 Suppressor APC domain containing 2 NM_001081085 11.96 0.0001 3.30 0.0040 Plays a critical role in cell cycle progression
 Iqgap3 IQ motif containing GTPase activating protein 3 NM_001033484 16.36 0.0002 3.88 0.0019 Unknown
 Raet1c Retinoic acid early transcript gamma NM_009018 15.69 0.0001 4.83 0.0011 Unknown