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Table 2 Primary adherence outcomes

From: Adherence to treatment with artemether–lumefantrine or amodiaquine–artesunate for uncomplicated malaria in children in Sierra Leone: a randomized trial

  Site 1 Site 2
AL AQAS OR (95%CI)
p-value*
AL AQAS OR (95%CI)
p-value*
Per-Protocol N = 175 N = 172   N = 165 N = 168  
Primary adherence outcomea
 Definitely non-adherent 2 (1.1%) 3 (1.7%) 2.16 (1.34− 3.49)
0.001
10 (6.1%) 5 (3.0%) 1.53 (1.00− 2.33)
0.049
 Probably non-adherent 4 (2.3%) 4 (2.3%) 4 (2.4%) 1 (0.6%)
 Probably adherent 30 (17.1%) 56 (32.6%) 65 (39.4%) 99 (58.9%)
 Definitely adherent 139 (79.4%) 109 (63.4%) 86 (52.1%) 63 (37.5%)
Self-reported adherenceb
 Non-adherent 6 (3.4%) 7 (4.1%) 1.19 (0.39− 3.63)
0.753
14 (8.5%) 6 (3.6%) 0.40 (0.15− 1.07)
0.067
 Adherent 169 (96.6%) 165 (95.9%) 151 (91.5%) 162 (96.4%)
Adherence based on packagingc
 Non-adherent 36 (20.6%) 63 (36.6%) 2.23 (1.38− 3.61)
0.001
79 (47.9%) 105 (62.5%) 1.81 (1.17− 2.81)
0.008
 Adherent 139 (79.4%) 109 (63.4%) 86 (52.1%) 63 (37.5%)
Intention-to-treat N = 179 N = 174   N = 178 N = 176  
Primary adherence outcomed
 Definitely non-adherent 2 (1.1%) 3 (1.7%) 2.15 (1.35− 3.44)
0.001
11 (6.2%) 6 (3.4%) 1.40 (0.93− 2.10)
0.109
 Probably non-adherent 4 (2.3%) 4 (2.3%) 4 (2.3%) 1 (0.6%)
 Probably adherent 32 (17.9%) 58 (33.3%) 73 (41.0%) 101 (57.4%)
 Definitely adherent 141 (78.8%) 109 (62.6%) 90 (50.6%) 68 (38.6%)
Self-reported adherenceb
 Non-adherent 6 (3.4%) 7 (4.0%) 1.21 (0.40− 3.67)
0.738
15 (8.4%) 7 (4.0%) 0.45 (0.18− 1.13)
0.090
 Adherent 173 (96.7%) 167 (96.0%) 163 (91.6%) 169 (96.0%)
Adherence based on packagingc
 Non-adherent 38 (21.2%) 65 (37.4%) 2.21 (1.38− 3.55)
0.001
88 (49.4%) 108 (61.4%) 1.62 (1.06− 2.48)
0.024
 Adherent 141 (78.8%) 109 (62.6%) 90 (50.6%) 68 (38.6%)
  1. *Odds Ratios were calculated using ordinal logistic regression for the primary adherence outcome and logistic regression for the binary outcomes with ORs calculated using AQAS as the reference group
  2. aDefinitely adherent = self-reported adherence + empty package; probably adherent = self-reported adherence (no package); probably non-adherent = self-reported non-adherence (no package); definitely non-adherent = self-reported non-adherence + package with tablets remaining
  3. bAdherent = definitely adherent + probably adherent
  4. cAdherent = only definitely adherent