Table 2 Primary adherence outcomes
Site 1 | Site 2 | |||||
|---|---|---|---|---|---|---|
AL | AQAS | OR (95%CI) p-value* | AL | AQAS | OR (95%CI) p-value* | |
Per-Protocol | N = 175 | N = 172 | N = 165 | N = 168 | ||
Primary adherence outcomea | ||||||
Definitely non-adherent | 2 (1.1%) | 3 (1.7%) | 2.16 (1.34− 3.49) 0.001 | 10 (6.1%) | 5 (3.0%) | 1.53 (1.00− 2.33) 0.049 |
Probably non-adherent | 4 (2.3%) | 4 (2.3%) | 4 (2.4%) | 1 (0.6%) | ||
Probably adherent | 30 (17.1%) | 56 (32.6%) | 65 (39.4%) | 99 (58.9%) | ||
Definitely adherent | 139 (79.4%) | 109 (63.4%) | 86 (52.1%) | 63 (37.5%) | ||
Self-reported adherenceb | ||||||
Non-adherent | 6 (3.4%) | 7 (4.1%) | 1.19 (0.39− 3.63) 0.753 | 14 (8.5%) | 6 (3.6%) | 0.40 (0.15− 1.07) 0.067 |
Adherent | 169 (96.6%) | 165 (95.9%) | 151 (91.5%) | 162 (96.4%) | ||
Adherence based on packagingc | ||||||
Non-adherent | 36 (20.6%) | 63 (36.6%) | 2.23 (1.38− 3.61) 0.001 | 79 (47.9%) | 105 (62.5%) | 1.81 (1.17− 2.81) 0.008 |
Adherent | 139 (79.4%) | 109 (63.4%) | 86 (52.1%) | 63 (37.5%) | ||
Intention-to-treat | N = 179 | N = 174 | N = 178 | N = 176 | ||
|---|---|---|---|---|---|---|
Primary adherence outcomed | ||||||
Definitely non-adherent | 2 (1.1%) | 3 (1.7%) | 2.15 (1.35− 3.44) 0.001 | 11 (6.2%) | 6 (3.4%) | 1.40 (0.93− 2.10) 0.109 |
Probably non-adherent | 4 (2.3%) | 4 (2.3%) | 4 (2.3%) | 1 (0.6%) | ||
Probably adherent | 32 (17.9%) | 58 (33.3%) | 73 (41.0%) | 101 (57.4%) | ||
Definitely adherent | 141 (78.8%) | 109 (62.6%) | 90 (50.6%) | 68 (38.6%) | ||
Self-reported adherenceb | ||||||
Non-adherent | 6 (3.4%) | 7 (4.0%) | 1.21 (0.40− 3.67) 0.738 | 15 (8.4%) | 7 (4.0%) | 0.45 (0.18− 1.13) 0.090 |
Adherent | 173 (96.7%) | 167 (96.0%) | 163 (91.6%) | 169 (96.0%) | ||
Adherence based on packagingc | ||||||
Non-adherent | 38 (21.2%) | 65 (37.4%) | 2.21 (1.38− 3.55) 0.001 | 88 (49.4%) | 108 (61.4%) | 1.62 (1.06− 2.48) 0.024 |
Adherent | 141 (78.8%) | 109 (62.6%) | 90 (50.6%) | 68 (38.6%) | ||