Per-Protocol | Site 1 | Site 2 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|

Treatment adherence^{a}
| AL (N = 176) | AQAS (N = 176) | Difference in means | 95% CI | p-value | AL (N = 173) | AQAS (N = 181) | Difference in means | 95% CI | p-value |

Mean % of treatment (SD)^{b}
| 99.8% (2.5) | 98.6% (7.9) | 1.17 | − 0.09, 2.42 | 0.068 | 97.0% (12.8) | 99.2% (6.3) | − 2.19 | − 4.37, 0.00 | 0.050 |

Correct treatment^{c}
| AL (N = 179) | AQAS (N = 174) | Odds Ratio | 95% CI | p-value | AL (N = 178) | AQAS (N = 176) | Odds ratio | 95% CI | p-value |
---|---|---|---|---|---|---|---|---|---|---|

Correct dose^{d}
| 163 (93.1%) | 144 (83.7%) | 2.64 | 1.30, 5.39 | 0.008 | 128 (77.6%) | 149 (88.7%) | 0.44 | 0.24, 0.81 | 0.008 |

Correct timing^{e}
| 163 (93.1%) | 166 (96.5%) | 0.49 | 0.18, 1.34 | 0.165 | 136 (82.4%) | 163 (97.0%) | 0.14 | 0.05, 0.38 | < 0.001 |

Correct duration^{f}
| 172 (98.3%) | 170 (98.8%) | 0.67 | 0.11, 4.09 | 0.668 | 156 (95.6%) | 164 (97.6%) | 0.42 | 0.13, 1.40 | 0.159 |

Correct treatment^{g}
| 154 (88.0%) | 140 (81.4%) | 1.68 | 0.92, 3.04 | 0.089 | 125 (75.8%) | 148 (88.1%) | 0.42 | 0.23, 0.76 | 0.004 |

Intention-to-treat | Site 1 | Site 2 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|

Treatment adherence^{a}
| AL (N = 175) | AQAS (N = 172) | Difference in means | 95% CI | p-value | AL (N = 165) | AQAS (N = 168) | Difference in means | 95% CI | p-value |

Mean % of treatment (SD)^{b}
| 99.8% (2.5) | 98.7% (7.9) | 1.14 | − 0.09, 2.36 | 0.069 | 97.0% (12.7) | 99.1% (6.0) | − 2.30 | − 4.40, − 0.19 | 0.032 |

Correct treatment^{c}
| AL (N = 175) | AQAS (N = 172) | Odds Ratio | 95% CI | p-value | AL (N = 165) | AQAS (N = 168) | Odds Ratio | 95% CI | p-value |
---|---|---|---|---|---|---|---|---|---|---|

Correct dose^{d}
| 166 (92.7%) | 146 (83.9%) | 2.45 | 1.22, 4.90 | 0.011 | 138 (77.5%) | 155 (88.1%) | 0.47 | 0.26, 0.83 | 0.010 |

Correct timing^{e}
| 166 (92.7%) | 168 (96.6%) | 0.45 | 0.17, 1.23 | 0.120 | 149 (83.7%) | 170 (96.6%) | 0.18 | 0.07, 0.45 | < 0.001 |

Correct duration^{f}
| 179 (97.8%) | 174 (98.9%) | 0.51 | 0.09, 2.81 | 0.439 | 169 (94.9%) | 171 (97.2%) | 0.55 | 0.18, 1.67 | 0.291 |

Correct treatment^{g}
| 156 (87.2%) | 142 (81.6%) | 1.53 | 0.85, 2.74 | 0.153 | 135 (75.8%) | 154 (87.5%) | 0.45 | 0.26, 0.79 | 0.005 |