Table 1 Test performance/cut-off activity/country
| Â | Laos | Cambodia | Â | ||||
|---|---|---|---|---|---|---|---|
Sensitivity (95%CI) (TP/TP+FN) | Specificity (95%CI) (TN/TN+FP) | ROC area (95%CI) | Sensitivity (95%CI) (TP/TP+FN) | Specificity (95%CI) (TN/TN+FP) | ROC area (95%CI) | p* | |
Cut-off activity = 10% | |||||||
 FSTdefint | 100.0% (71.5–100.0) (11/11) | 86.73% (84.1–89.1) (647/746) | 0.934 (0.921–0.946) | 100.0% (92.0–100.0) (44/44) | 56.2% (51.5–60.7) (259/461) | 0.781 (0.758–0.804) | < 0.001 |
 FSTdef | 100.0% (71.5–100.0) (11/11) | 96.25% (94.6–97.5) (718/746) | 0.981 (0.974–0.988) | 97.7% (88.0–99.9) (43/44) | 80.5% (76.6–74.0) (371/461) | 0.891 (0.862–0.920) | < 0.001 |
 RDT | 100.0% (71.5–100.0) (11/11) | 94.88% (93.0–96.4) (704/742) | 0.974 (0.966–0.982) | 97.6% (87.1–99.9) (40/41) | 75.3% (71.1–79.2) (344/457) | 0.864 (0.833–0.895) | < 0.001 |
Cut-off activity = 30% | |||||||
 FSTdefint | 100.0% (90.1–100.0) (39/39) | 90.1% (87.7–92.2) (647/718) | 0.951 (0.940–0.961) | 97.9% (94.1–99.6) (142/145) | 71.1% (66.1–75.7) (256/360) | 0.845 (0.819–0.871) | < 0.001 |
 FSTdef | 100.0% (90.1–100.0) (39/39) | 100.0% (99.5–100.0) (718/718) | 1.000 (1.000–1.000) | 89.7% (83.5–94.1) (130/145) | 99.2% (97.5–99.8) (357/360) | 0.944 (0.920–0.969) | < 0.001 |
 RDT | 100.0% (90.1–100.0) (39/39) | 98.6% (97.4–99.3) (704/714) | 0.993 (0.989–0.997) | 91.4% (85.5–95.5) (128/140) | 93.0% (89.9–95.4) (333/358) | 0.922 (0.895–0.949) | < 0.001 |
Cut-off activity = 70% | |||||||
 FSTdefint | 80.0% (67.7–89.2) (48/60) | 91.1 (88.7–93.1) (635/697) | 0.856 (0.803–0.908) | 71.9% (66.3–77.0) (207/288) | 82.0% (76.3–86.9) (178/217) | 0.770 (0.733–0.806) | < 0.001 |
 FSTdef | 65.0% (51.6–76.8) (39/60) | 100.0% (99.5–100.0) (697/697) | 0.825 (0.764–0.886) | 46.2% (40.3–52.1) (133/288) | 100.0% (98.3–100.0) (217/217) | 0.731 (0.702–0.760) | < 0.001 |
 RDT | 73.3% (60.3–83.9) (44/60) | 99.3% (98.3–99.8) (688/693) | 0.863 (0.807–0.920) | 53.4% (47.3–59.3) (151/283) | 99.1% (96.7–99.9) (213/215) | 0.762 (0.732–0.792) | < 0.001 |