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Table 3 Diagnostic evaluation test of LAMP and RDT with nPCR as the gold standard

From: Evaluation of loop-mediated isothermal amplification as a surveillance tool for malaria in reactive case detection moving towards elimination

  Total number tested Number positive (%) Number negative (%) Sensitivity 95% confidence interval Specificity 95% confidence interval Positive predictive value
95% confidence interval
Negative predictive value
95% confidence interval
RDTs 2642 23 2619 9.30% (2.59–22.14%) 99.24% (98.86–99.56%) 17.39% (6.96–37.22%) 98.51% (98.36–98.65%)
LAMP extracted from RDT 2642 45 2597 95.35% (84.19–99.43%) 99.85% (99.61–99.96%) 99.11% (79.34–96.47%) 99.92% (99.70–99.88%)
LAMP extracted from DBS 2640 47 2593 95.50% (84.85–99.46%) 99.92% (99.72–99.99%) 95.56% (84.31–98.85%) 99.92% (99.70–99.98%)
nPCR extracted from DBS 315 43 262 Reference Reference Reference Reference
  1. RDTs rapid diagnostic test, LAMP loop-mediated amplification, DBS dried blood spot, nPCR nested polymerase chain reaction