Table 3 Diagnostic evaluation test of LAMP and RDT with nPCR as the gold standard
| Â | Total number tested | Number positive (%) | Number negative (%) | Sensitivity 95% confidence interval | Specificity 95% confidence interval | Positive predictive value 95% confidence interval | Negative predictive value 95% confidence interval |
|---|---|---|---|---|---|---|---|
RDTs | 2642 | 23 | 2619 | 9.30% (2.59–22.14%) | 99.24% (98.86–99.56%) | 17.39% (6.96–37.22%) | 98.51% (98.36–98.65%) |
LAMP extracted from RDT | 2642 | 45 | 2597 | 95.35% (84.19–99.43%) | 99.85% (99.61–99.96%) | 99.11% (79.34–96.47%) | 99.92% (99.70–99.88%) |
LAMP extracted from DBS | 2640 | 47 | 2593 | 95.50% (84.85–99.46%) | 99.92% (99.72–99.99%) | 95.56% (84.31–98.85%) | 99.92% (99.70–99.98%) |
nPCR extracted from DBS | 315 | 43 | 262 | Reference | Reference | Reference | Reference |