Table 2 Analysis of anaemia and haemolysis in subclinically Plasmodium falciparum infected children grouped by haemoglobin genotype
Genotype | HbAA (n = 15) | HbAC (n = 4) | P-value (HbAA v. HbAC) | HbAS (n = 1) | HbSC (n = 1) |
|---|---|---|---|---|---|
Median (range) | Median (range) | Value | Value | ||
Day 0 | |||||
Patients (n) | 15 | 4 | 1 | 1 | |
Hb (g/dL) | 11.9 (9.8–14.3) | 11.4 (10.7–13.8) | 0.90 | 11.2 | 9.3 |
Haem (uM) | 23.1 (13–142.3) | 17.5 (11.7–23.1) | 0.19 | 11.2 | 21.4 |
HO-1 (ng/mL) | 2.4 (0.3–6.8) | 3.3 (1.0–4.2) | 0.73 | 0.6 | 7.6 |
Day 35 | |||||
Patients (n) | 14 | 4 | 1 | 1 | |
Hb (g/dL) | 11.1 (9.6–14.9) | 11.2 (10.3–13.7) | 0.98 | 12.3 | 8.8 |
Haem (uM) | 16.2 (8.2–38.2) | 16.3 (9.3–22.8) | 0.86 | 10.3 | 25.5 |
HO-1 (ng/mL) | 0.7 (0.4–4.0) | 1.2 (0.1–11.5) | 0.82 | 1.2 | 2.5 |
All Dates | |||||
Patients (n) | 29 | 8 | |||
Hb (g/dL) | 11.7 (9.6–14.9) | 11.4 (10.3–13.8) | 0.93 | ND | ND |
Haem (uM) | 17.1 (8.2–142.3) | 17.5 (9.3–23.1) | 0.44 | ND | ND |
HO-1 (ng/mL) | 1.3 (0.3–6.8) | 2.4 (0.1–11.5) | 0.57 | ND | ND |