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Table 4 Accuracy of LM, RDT and LAMP for diagnosing symptomatic and asymptomatic malaria in peripheral blood

From: Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) for screening malaria in peripheral and placental blood samples from pregnant women in Colombia

 

Value (95% CI)

Sensitivity

Specificity

PPV

NPV

Kappa

Symptomatic (N = 50)a

 LM

100.0% (85.7–100.0)

100.0% (87.5–100.0)

100.0% (85.7–100.0)

98.7% (87.5–100.0)

1.0 (1.0–1.0)

 RDT

95.0% (76.4–99.0)

100.0% (87.5–100.0)

100.0% (83.2–100.0)

96.3% (82.3–99.4)

1.0 (0.9–1.0)

 LAMP

100.0% (85.7–100.0)

100.0% (87.5–100.0)

100.0% (85.7–100.0)

98.7% (87.5–100.0)

1.0 (1.0–1.0)

Asymptomatic (N = 437)a

 LM

50.0% (28.0–72.0)

100.0% (99.1–100.0)

100.0% (67.6–100.0)

98.0% (96.4–99.1)

0.7 (0.4–0.9)

 RDT

50.0% (28.0–72.0)

100.0% (99.1–100.0)

100.0% (67.6–100.0)

98.0% (96.4–99.1)

0.7 (0.4–0.9)

 LAMP

100.0% (80.6–100.0)

100.0% (99.1–100.0)

100.0% (80.6–100.0)

100.0% (99.1–100.0)

1.0 (1.0–1.0)

  1. LM light microscopy, RDT rapid diagnostic test, LAMP loop-mediated isothermal amplification, PPV positive predictive value, NPV negative predictive value, CI confidence interval, N sample size
  2. anPCR was used as the reference test
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Malaria Journal

ISSN: 1475-2875

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