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Table 4 Sequence polymorphism in 4 conserved domains of pmcsp

From: Genetic polymorphisms in the circumsporozoite protein of Plasmodium malariae show a geographical bias

Haplotype Amino acid Number (area#)
  Conserved region 1  
1 PVEKKLNHP 1 (KE)
2 PVENKLKQP 1 (TH)
3 PVENKLKHP 1 (TH)
4 PFENNLNHP 1 (LA)
5 AVENKLKQP 36 (TH), 34 (KE), 30 (MM), 12 (CA), 2 (CH), 1 (LA), 1 (BA), 1 (UG), 1 (IV)
6 AVENKLKHP 10 (MM), 3 (KE), 3 (TH), 3 (LA)
7 AVENNLKQP 2 (TH)
  Th2R
1 GPSEELLKNFLESIRNS 1 (MM), 1 (LA)
2 GPYEEHIKNYLESIRNS 1 (CA)
3 GPSEEHIKNIIESIRNS 1 (KE)
4 GPSEEHIKNYLKSIRNS 1 (MM)
5 GPSEEHIKNYLESIRNS 43 (TH), 37 (KE), 32 (MM) 11 (CA), 3 (LA), 2 (CH), 1 (BA), 1 (UG), 1 (IV)
6 GPSEELIKNFLESIRNS 5 (MM), 2 (TH)
  Conserved region 2  
1 ITEEWPPCSVTCG 6 (MM)
2 ITEKWSPCSVTCG 1 (LA), 1 (MM)
3 ITEEWSPCTVTCG 1 (LA)
4 ITEEWSPCSVTCG 43 (TH), 38 (KE), 33 (MM), 12 (CA), 3 (LA), 2 (CH), 1 (BA), 1 (IV), 1 (UG)
  Th3R  
1 KKVDAKNKKPAELVLSDLE 1 (MM)
2 KKVDAKNKKPAKLVLSDLE 1 (MM)
3 RKDDAKNKKPAELVLSDLE 13 (KE)
4 RKVNAKNKKPAELVLSDLE 1 (KE)
5 RKVDAKNKKPAELVLSDLE 41 (TH), 28 (MM), 21 (KE), 10 (CA), 3 (LA), 2 (CH), 1 (BA), 1 (IV)
6 RKVDAKNKKPAELVLSDVE 10 (MM), 2 (TH), 2 (LA)
7 RKVGAKNKKPAELVLSDLE 2 (KE), 1 (CA), 1 (UG)
8 RMVDAKNKKPEELVLSDLE 1 (KE)
9 REVDAKNKKPAELVLSDLE 1 (CA)
  1. # TH, Thailand; MM, Myanmar; LA, Lao PDR; BA, Bangladesh; KE, Kenya; CH, China; CA, Cameroon; UG, Uganda; IV, Cote d’Ivote