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Table 2 Polymorphism analysis of inhibitory B-cell epitopes

From: Diversity pattern of Duffy binding protein sequence among Duffy-negatives and Duffy-positives in Sudan

Epitopea Position (amino acid) Epitope sequence (based on Sal-1) S Si Pa K H Hd ± SD π ± SD dN − dS Taj D D* (F&L) F* (F&L)
H1 306–321 FHRDITFRKLYLKRKL 1 0 1 0.3 2 0.28 ± 0.077 0.00593 ± 0.001 0.007 0.31 0.55 0.56
H2 328–341 EGDLLLKLNNYRYN 0 0 0 0 0 0 0 0 0 0 0
H3 384–399 DEKAQQRRKQWWNESK 5 0 5 1.6 6 0.81 ± 0.020 0.0341 ± 0.002 1.99b 1.68 1.11 1.27
M1 344–355 FCKDIRWSLGDF 0 0 0 0 0 0 0 0 0 0 0
M2 414–429 LKGNFIWICKLNVAVN 2 0 2 0.6 3 0.401 ± 0.085 0.012 ± 0.002 1.36 0.48 0.48 0.76
M 3 432–447 PQIYRWIREWGRDYVS 2 0 2 0.5 4 0.452 ± 0.078 0.010 ± 0.002 0.02 0.17 0.76 0.68
L2 400–411 AQIWTAMMYSVK 0 0 0 0 0 0 0 0 0 0 0
L3 364–377 MEGIGYSKVVENNL 1 0 1 0.5 2 0.511 ± 0.019 0.011 ± 0.0004 1.1 1.68 0.55 1.01
L1 282–293 CIPDRRYQLCMK 0 0 0 0 0 0 0 0 0 0 0
L4 272–286 DWDCNTKKDVCIPD 0 0 0 0 0 0 0 0 0 0 0
  1. a[18]; b p < 0.02; S = number of variable (segregating) sites, Si = singleton variable sites, Pa = parsimony informative sites, K = average number of pair-wise nucleotide differences, H = number of haplotypes, Hd = haplotype diversity, SD = standard deviation, π = nucleotide diversity, dN = non synonymous substitution, dS = synonymous substitution, D⁄(F&L) = Fu and Li’s D⁄ test statistic, F⁄(F&L) = Fu and Li’s F⁄ test statistic. Bold and underline indicate polymorphic amino acid residues