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Table 2 Polymorphism analysis of inhibitory B-cell epitopes

From: Diversity pattern of Duffy binding protein sequence among Duffy-negatives and Duffy-positives in Sudan

Epitopea

Position (amino acid)

Epitope sequence (based on Sal-1)

S

Si

Pa

K

H

Hd ± SD

π ± SD

dN − dS

Taj D

D* (F&L)

F* (F&L)

H1

306–321

FHRDITFRKLYLKRKL

1

0

1

0.3

2

0.28 ± 0.077

0.00593 ± 0.001

0.007

0.31

0.55

0.56

H2

328–341

EGDLLLKLNNYRYN

0

0

0

0

0

0

0

0

0

0

0

H3

384–399

DEKAQQRRKQWWNESK

5

0

5

1.6

6

0.81 ± 0.020

0.0341 ± 0.002

1.99b

1.68

1.11

1.27

M1

344–355

FCKDIRWSLGDF

0

0

0

0

0

0

0

0

0

0

0

M2

414–429

LKGNFIWICKLNVAVN

2

0

2

0.6

3

0.401 ± 0.085

0.012 ± 0.002

1.36

0.48

0.48

0.76

M 3

432–447

PQIYRWIREWGRDYVS

2

0

2

0.5

4

0.452 ± 0.078

0.010 ± 0.002

0.02

0.17

0.76

0.68

L2

400–411

AQIWTAMMYSVK

0

0

0

0

0

0

0

0

0

0

0

L3

364–377

MEGIGYSKVVENNL

1

0

1

0.5

2

0.511 ± 0.019

0.011 ± 0.0004

1.1

1.68

0.55

1.01

L1

282–293

CIPDRRYQLCMK

0

0

0

0

0

0

0

0

0

0

0

L4

272–286

DWDCNTKKDVCIPD

0

0

0

0

0

0

0

0

0

0

0

  1. a[18]; b p < 0.02; S = number of variable (segregating) sites, Si = singleton variable sites, Pa = parsimony informative sites, K = average number of pair-wise nucleotide differences, H = number of haplotypes, Hd = haplotype diversity, SD = standard deviation, π = nucleotide diversity, dN = non synonymous substitution, dS = synonymous substitution, D⁄(F&L) = Fu and Li’s D⁄ test statistic, F⁄(F&L) = Fu and Li’s F⁄ test statistic. Bold and underline indicate polymorphic amino acid residues