Table 4 Drug threshold values for GAP MCB parasites

CQ (chloroquine)

IC50 (nM)

14.85

206.8

14.37

16.53

297.6

13.77

95% confidence intervals (nM)

(8.489–25.98)

(131.6–325.0)

(8.671–23.80)

(9.880–27.64)

(179.3–493.9)

(8.149–23.28)

DHA (dihydroartemisinin)

IC50 (nM)

5.624

4.354

4.931

7.366

2.019

7.943

95% confidence intervals (nM)

(4.271–7.406)

(2.902–6.532)

(3.667–6.629)

(5.600–9.689)

(1.539–2.649)

(6.065–10.40)

PQ (piperaquine)

IC50 (nM)

18.15

46.02

15.27

30.69

48.85

23.59

95% confidence intervals (nM)

(10.41–31.66)

(29.78–71.11)

(8.490–27.47)

(19.33–48.72)

(34.94–68.31)

(15.29–36.39)

LF (lumefantrine)

IC50 (nM)

No results

70.35

No results

No results

42.32

No results

315.2

25.31

335.8

95% confidence intervals (nM)

(46.35–106.8)

(33.26–53.85)

(205.2–484.3)

(18.11–35.38)

(251.3–448.7)

AQM (desethylamodiaquine)

IC50 (nM)

10.19

66.83

10.35

18.46

83.88

15.55

95% confidence intervals (nM)

(6.031–17.21)

(40.88–109.3)

(5.551–19.31)

(10.06–33.86)

(48.10–146.3)

(9.139–26.47)

ATQ (atovaquone)

IC50 (nM)

0.9587

1.939

1.147

0.7122

1.524

1.216

95% confidence intervals (nM)

(0.8493–1.082)

(1.752–2.147)

(0.9806–1.342)

(0.6224–0.8150)

(1.304–1.781)

(1.094–1.352)

PD (pyronaridine)

IC50 (nM)

5.398

9.897

7.804

27.67

21.88

12.59

95% confidence intervals (nM)

(3.359–8.675)

(5.615–17.45)

(3.473–17.54)

(15.88–48.19)

(11.82–40.49)

(6.720–23.57)

MQ (mefloquine HCl)

IC50 (nM)

101.5

15.32

98.87

157

12.26

61.27

95% confidence intervals (nM)

(72.61–141.8)

(10.85–21.65)

(69.17–141.3)

(79.04–311.8)

(8.573–17.53)

(43.67–85.96)

QN (quinine HCl)

IC50 (nM)

203.2

795.6

227.4

335.6

569.6

89.73

95% confidence intervals (nM)

(169.9–243.0)

(527.6–1200)

(173.1–298.8)

(195.2–577.1)

(432.1–750.9)

(62.87–128.1)