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Table 3 Secondary parameters for mefloquine

From: Population pharmacokinetics of mefloquine given as a 3-day artesunate–mefloquine in patients with acute uncomplicated Plasmodium falciparum malaria in a multidrug-resistant area along the Thai–Myanmar border

 

Cured infection median (min–max) (n = 93)

Recrudescent infection median (min–max) (n = 36)

p-values

Cmax (ng/ml)

2050 (1290–2410)

1980 (1280–2370)

0.0107

Tmax (h)

7.54 (3.76–18.2)

7.50 (4.92–16.6)

0.832

AUC0–150days (µg*h/ml)

450 (144–731)

455 (227–831)

0.554

t1/2 (days)

9.72 (1.97–16.7)

10.3 (5.58–17.9)

0.0449

  1. Cmax, maximum concentration; Tmax, time to reach the maximum concentration; AUC0–150days, area under the concentration–time curve from the first dose to day 150 after the first dose; t1/2, terminal elimination half-life. P-values were calculated using an unpaired t test
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Malaria Journal

ISSN: 1475-2875

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