Table 3 Clinical characteristics, drug concentrations and genotyping of Plasmodium vivax among patients with recurrences
Patient 1 | Patient 2 | Patient 3 | Patient 4 | |
|---|---|---|---|---|
Age (years) | 22 | 57 | 20 | 60 |
Gender | Male | Male | Male | Male |
Weight (kg) | 84.7 | 83 | 70 | 60 |
Body mass index | 28.40 | 29.76 | 25.40 | 23.73 |
Past h/o malaria | Yes | No | Yes | No |
Clinical phenotype of index episode | Non-severe | Non-severe | Non-severe | Non-severe |
Schizonticidal drug | Chloroquine | Artesunate + Doxycycline | Chloroquine | Chloroquine |
Regimen of PQ | High | Low | Low | High |
Actual dose of PQ received (mg/day) | 45.0 | 22.5 | 15.0 | 30.0 |
Actual dose of PQ received (mg/kg) | 0.53 | 0.27 | 0.21 | 0.50 |
Time to first recurrence (days) | 105 | 100 | 93 | 80 |
Clinical phenotype of recurrent episode | Non-severe | Non-severe | Non-severe | Non-severe |
Schizonticidal drug of recurrence | Chloroquine | Chloroquine | Chloroquine | Chloroquine |
PQ dose during recurrent episode (mg/day) | 45.0 | 15.0 | 37.5 | 30.0 |
Drug levels during index episode | ||||
PQ Level (µg/ml) | 6.518 | 0.240 | 0.159 | NA |
CPQ Level (µg/ml) | 4.714 | 8.026 | 0.746 | NA |
Drug levels during recurrence | ||||
PQ Level (µg/ml) | 0.267 | NA | 0.399 | NA |
CPQ Level (µg/ml) | 3.873 | NA | 0.536 | NA |
Amplicon sizes (MS7) | ||||
Initial infection | 342 | 351 | 351 | 345 |
Recurrent infection | 342 | 351 | 351 | 345 |
Amplicon sizes (MS10) | ||||
Initial infection | 263 | 254 | 290 | 290 |
Recurrent infection | 263 | 254 | 290 | 290 |