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Table 6 Sensitivity and specificity between different groups of age

From: Comparison of three diagnostic methods (microscopy, RDT, and PCR) for the detection of malaria parasites in representative samples from Equatorial Guinea

Age group

PCR

Total

SV (95% CI)

SpV (95% CI)

PPV (95% CI)

NPV (95% CI)

Neg.

Posit.

RDT vs. PCR

 ≤ 12 months (n = 394)

  Neg.

282

11

293

88.17 (80.05–93.27)

93.69 (90.35–95.92)

81.19 (73.07–89.30)

96.25 (93.90–98.59)

  Posit.

19

82

101

 13 months–5 years (n = 513)

  Neg.

243

17

260

92.41 (88.18–95.21)

84.08 (79.42–87.85)

81.82 (76.87–86.77)

93.46 (90.26–96.66)

  Posit.

46

207

253

 6–15 years (n = 505)

  Neg.

137

49

186

85.5 (81.35–88.86)

82.04 (75.51–87.12)

90.60 (87.24–93.96)

73.66 (67.06–80.26)

  Posit.

30

289

319

 > 15 years (n = 309)

  Neg.

171

51

222

61.07 (52.52–68.99)

96.07 (92.11–98.08)

91.95 (85.66–98.24)

77.03 (71.27–82.79)

  Posit.

7

80

87

Microscopy vs. PCR

 ≤ 12 months (n = 394)

  Neg.

239

42

281

54.84 (44.73–64.56)

79.4 (74.48–83.59)

45.13 (35.52–54.75)

85.05 (80.71–89.40)

  Posit.

62

51

113

 13 months–5 years (n = 513)

  Neg.

222

78

300

65.18 (58.73–71.11)

76.82 (71.62–81.31)

68.54 (62.07–75.02)

74 (68.87–79.13)

  Posit.

67

146

213

 6–15 years (n = 505)

  Neg.

127

138

265

59.17 (53.86–64.28)

76.05 (69.04–81.89)

83.33 (78.41–88.26)

47.92 (41.72–54.13)

  Posit.

40

200

240

 > 15 years (n = 309)

  Neg.

145

77

222

41.22 (33.16–49.78)

81.46 (75.11–86.48)

62.07 (51.30–72.84)

65.32 (58.83–71.80)

  Posit.

33

54

87

  1. The table shows the sensitivity and specificity in different groups of age as well as the positive predictive value and negative predictive value. The most important thing is the decrease of the sensitivity of microscopy and RDTs with the age. SV sensitivity value, SpV specificity value, PPV positive predictive value (95% CI), NPV negative predictive value (95% CI)
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Malaria Journal

ISSN: 1475-2875

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