From: Proteomic profiling of the plasma of Gambian children with cerebral malaria
Survived (N = 26) | Died (N = 26) | P value | |
---|---|---|---|
Sex (male/female) | 14/15 | 15/9 | 0.33 |
Age (median, IQR) months | 60 (35–95) | 48 (24–83) | 0.32 |
Hb (mean, SD) g/dl | 7.27 (1.93) | 8.03 (2.15) | 0.07 |
Respiratory distressa (%) | 24.1 | 66.6 | 0.002 |
Convulsions on admission (%) | 75 | 69.2 | 0.77 |
Deep coma (%)a | 31 | 54 | 0.08 |
Transfused (%) | 37.9 | 45.8 | 0.56 |
P. falciparum (geo mean, 95% CI) parasites/µl | 35,341 (18,759–66,581) | 55,792 (28,797–108,095) | 0.051 |
Protein biomarkers | |||
Circulating 20S proteasomes (ng/ml) | 39.4 (19.6–49.4) | 22.7 (16–34.5) | 0.20 |
PSMB9 (ng/ml) | 177 (129–267) | 209 (161–271) | 0.49 |