Efficacy of artemether–lumefantrine and dihydroartemisinin–piperaquine for the treatment of uncomplicated malaria in Papua New Guinea

Table 6 In vitro drug susceptibility measured in the Plasmodium falciparum isolates collected in Maprik and Alotau and comparison with results from study previously conducted in Madang (2011–2013)

Drug	Maprik			Alotau			Maprik vs Alotau	Madang [20]			Maprik vs Madang	Alotau vs Madang	Cut-off (nM)**
Drug	N	Mean	95% CI	N	Mean	95% CI	P-value*	N	Mean	95% CI	P-value*	P-value*	Cut-off (nM)**
Chloroquine	49	65.26	50.04–85.1	47	74.00	59.38–92.21	0.59	48	86.76	70.66–106.5	0.09	0.19	≥ 100
Lumefantrine	49	6.04	4.74–7.7	47	7.97	6.46–9.82	0.18	44	1.55	1.14–2.1	< 0.0001	< 0.0001	≥ 150
Naphthoquine	49	7.30	6.1–8.73	47	8.79	7.41–10.42	0.19	47	4.24	3.13–5.76	0.0003	< 0.0001
Piperaquine	49	18.60	14.27–24.23	47	23.41	17.46–31.38	0.15	47	21.02	16.96–26.04	0.44	0.31
Pyronaridine	49	9.33	7.02–12.4	47	10.02	7.92–12.61	0.98	45	7.97	5.99–10.61	0.11	0.19

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