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Table 6 In vitro drug susceptibility measured in the Plasmodium falciparum isolates collected in Maprik and Alotau and comparison with results from study previously conducted in Madang (2011–2013)

From: Efficacy of artemether–lumefantrine and dihydroartemisinin–piperaquine for the treatment of uncomplicated malaria in Papua New Guinea

Drug Maprik Alotau Maprik vs Alotau Madang [20] Maprik vs Madang Alotau vs Madang Cut-off (nM)**
N Mean 95% CI N Mean 95% CI P-value* N Mean 95% CI P-value* P-value*
Chloroquine 49 65.26 50.04–85.1 47 74.00 59.38–92.21 0.59 48 86.76 70.66–106.5 0.09 0.19 ≥ 100
Lumefantrine 49 6.04 4.74–7.7 47 7.97 6.46–9.82 0.18 44 1.55 1.14–2.1 < 0.0001 < 0.0001 ≥ 150
Naphthoquine 49 7.30 6.1–8.73 47 8.79 7.41–10.42 0.19 47 4.24 3.13–5.76 0.0003 < 0.0001  
Piperaquine 49 18.60 14.27–24.23 47 23.41 17.46–31.38 0.15 47 21.02 16.96–26.04 0.44 0.31  
Pyronaridine 49 9.33 7.02–12.4 47 10.02 7.92–12.61 0.98 45 7.97 5.99–10.61 0.11 0.19  
  1. Values are presented as geometric mean IC50 and 95% confidence interval (CI)
  2. * Mann–Whitney U test
  3. ** Cut off values referring to in vivo resistance suggested in the literature