A randomized trial of dihydroartemisinin–piperaquine versus artemether–lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Mali

Table 2 Clinical and parasitological response at 28-day before and after PCR correction

Treatment arm outcome	AL n (%)	DHA–PQ n (%)	p-value
Before PCR correction
ETF	0 (0.00)	1 (0.7)	1
LCF	8 (5.2)	1 (0.7)	0.036
LPF	16 (10.3)	2 (1.2)	0.001
ACPR^a	131 (84.5)	151 (97.4)	< 0.001
Total	155 (100)	155 (100)
After PCR correction
ETF	0 (0.00)	1 (0.7)	1
LCF	0 (0.00)	0 (0.00)	–
LPF	3 (1.9)	0 (0.00)	0.3
ACPRc	152 (98.1)	154 (99.4)	0.3
Total	155 (100)	155 (100)

PCR corrected Adequate Clinical and Parasitological Response was study endpoint, ACPRc was not statistically different between DHA–PQ versus AL (p = 0.3)
^aNon PCR corrected Adequate Clinical and Parasitological Response (ACPR), was statistically different between DHA–PQ versus AL

ISSN: 1475-2875