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Table 2 Clinical and parasitological response at 28-day before and after PCR correction

From: A randomized trial of dihydroartemisinin–piperaquine versus artemether–lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Mali

Treatment arm outcome AL
n (%)
DHA–PQ
n (%)
p-value
Before PCR correction
 ETF 0 (0.00) 1 (0.7) 1
 LCF 8 (5.2) 1 (0.7) 0.036
 LPF 16 (10.3) 2 (1.2) 0.001
 ACPRa 131 (84.5) 151 (97.4) < 0.001
 Total 155 (100) 155 (100)  
After PCR correction
 ETF 0 (0.00) 1 (0.7) 1
 LCF 0 (0.00) 0 (0.00)
 LPF 3 (1.9) 0 (0.00) 0.3
 ACPRc 152 (98.1) 154 (99.4) 0.3
 Total 155 (100) 155 (100)  
  1. PCR corrected Adequate Clinical and Parasitological Response was study endpoint, ACPRc was not statistically different between DHA–PQ versus AL (p = 0.3)
  2. aNon PCR corrected Adequate Clinical and Parasitological Response (ACPR), was statistically different between DHA–PQ versus AL