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Table 3 Molecular markers of P. falciparum anti-malarial resistance

From: Prevalence of Plasmodium falciparum infection among pregnant women at first antenatal visit in post-Ebola Monrovia, Liberia

Genes

SNP

Wild-type

Mutant

Pfmdr1

Multi-drug resistance

N86Y

8 (47.0%)

9 (52.9%)

L155L (Syn)

16 (94.1%)

1 (5.9%)

Y184F

7 (41.2%)

10 (58.8%)

S1034C

17 (100.0%)

0 (0%)

N1042D

17 (100.0%)

0 (0%)

D1246Y

15 (88.2%)

2 (11.8%)

Pfdhps

Sulfadoxine

S436A

12 (70.6%)

5 (29.4%)

A437G

14 (82.3%)

3 (17.6%)

K540E

17 (100.0%)

0 (0%)

A581G

16 (94.1%)

1 (5.9%)

A613S

15 (88.2%)

2 (11.8%)

Pfcrt

Chloroquine

M74I

2 (11.8%)

15 (88.2%)

N75E

2 (11.8%)

15 (88.2%)

K76T

2 (11.8%)

15 (88.2%)

I77I (Syn)

16 (94.1%)

1 (5.9%)

I103I (Syn)

16 (94.1%)

1 (5.9%)

K13

Artemisinin

V510V (Syn)

16 (94.1%)

1 (5.9%)

  1. SNP single nucleotide polymorphisms, Syn synonymous mutation (no amino acid change)