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Table 2 Treatment responses in patients treated with artesunate/amodiaquine, artemether/lumefantrine and dihydroartemisinin/piperaquine in Tanzania: PCR uncorrected

From: Efficacy and safety of artemisinin-based combination therapy, and molecular markers for artemisinin and piperaquine resistance in Mainland Tanzania

Year

Drug/site

N

PD3

Excluded/lost

LCF

LPF

ACPR

Kaplan–Meier

n (%)

n (%)

% (95% CI)

% (95% CI)

% (95% CI)

% (95% CI)

2011

ASAQ

 Ujiji

73

0

8 (11.0)

13.8 (6.5–24.7)

10.8 (4.4–20.9)

75.4 (63.1–85.2)

76.1 (64.0–84.6)

 Kibaha

29

0

4 (13.8)

0 (0.0–13.7)

0 (0.0–13.7)

100 (86.3–100)

100

AL

 Muheza

32

2 (6.3)

2 (6.3)

0 (0.0–11.6)

3.3 (0.1–17.2)

96.7 (82.8–99.9)

96.9 (79.8–99.6)

2012

AL

 Chamwino

26

0

3 (11.5)

0 (0.0–14.8)

4.3 (0.1–21.9)

95.7 (78.1–99.9)

95.7 (72.9–99.4)

 Kyela

44

0

8 (18.2)

5.6 (0.7–18.7)

16.7 (6.4–32.8)

77.8 (60.8–89.9)

78.9 (62.3–88.9)

 Nagaga

62

0

23 (37.1)

0 (0.0–9.0)

0 (0.0–9.0)

100 (91.0–100)

100

2015

AL

 Kyela

80

0

16 (20.0)

4.7 (1.0–13.1)

1.6 (0.0–8.4)

93.8 (84.8–98.3)

94.1 (85.0–97.8)

DHA-PQ

 Rufiji

82

0

10 (12.2)

1.4 (0.0–7.5)

0 (0.0–5.0)

98.6 (92.5–100)

98.6 (90.8–99.8)

  1. PD3 positive on day 3, LCF late clinical failure, LPF late parasitological failure, ACPR adequate clinical and parasitological response, ASAQ artesunate + amodiaquine, AL artemether + lumefantrine, DHAPQ dihydroartemisinin + piperaquine