Efficacy and safety of artemisinin-based combination therapy, and molecular markers for artemisinin and piperaquine resistance in Mainland Tanzania

Table 3 Treatment responses in patients treated with artesunate/amodiaquine, artemether/lumefantrine and dihydroartemisinin/piperaquine in Tanzania: PCR corrected

Year	Drug/site	N	Excluded/lost	Re-infection	Uknown	LCF	LPF	ACPR	Kaplan–Meier
Year	Drug/site	N	n (%)	n (%)	n (%)	% (95% CI)	% (95% CI)	% (95% CI)	% (95% CI)
2011	ASAQ
	Ujiji	73	8 (11.0)	12 (16.4)	3 (4.1)	0 (0.0–7.1)	2 (0.1–10.6)	98 (89.4–99.9)	98.3 (88.8–99.8)
	Kibaha	29	4 (13.8)	NA	NA	0 (0.0–13.7)	0 (0.0–13.7)	100 (86.3–100)	100
	AL
	Muheza	32	2 (6.3)	0	1 (3.1)	0 (0.0–11.9)	0 (0.0–11.9)	100 (88.1–100)	100
2012	AL
	Chamwino	26	3 (11.5)	0	0	0 (0.0–14.8)	4.3 (0.1–21.9)	95.7 (78.1–99.0)	95.7 (72.9–99.4)
	Kyela	44	8 (18.2)	3 (6.8)	2 (4.5)	6.5 (0.8–21.4)	3.2 (0.1–16.7)	90.3 (74.2–98.0)	91.5 (75.9–97.2)
	Nagaga	62	23 (37.1)	NA	NA	0 (0.0–9.0)	0 (0.0–9.0)	100 (91.0–100)	100
2015	AL
	Kyela	80	16 (20.0)	3 (3.8)	1 (1.3)	0 (0.0–6.0)	0 (0.0–6.0)	100 (94.0–100)	100
	DHA-PQ
	Rufiji	82	10 (12.2)	0	1 (1.2)	0 (0.0–5.1)	0 (0.0–5.1)	100 (94.9–100)	100

Unknown unknown based on PCR analysis, LCF late clinical failure, LPF late parasitological failure, ACPR adequate clinical and parasitological response, ASAQ artesunate/amodiaquine, AL artemether/lumefantrine, DHAPQ dihydroartemisinin/piperaquine