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Table 1 Sensitivity and specificity of PURE–LAMP, microscopy observation, and RDT compared to nested PCR

From: Combination of PURE-DNA extraction and LAMP-DNA amplification methods for accurate malaria diagnosis on dried blood spots

Test

Sensitivity [95% CI]

Specificity [95% CI]

PURE–LAMP Pan

96.96% [89.47–99.63]

100%

PURE–LAMP Pf

97.82% [88.47–99.94]

100%

Microscopy

93.93% [85.20–98.32]

100%

RDT

T1: 100%

T2: 68.18% [55.56–79.11]

T1: 92.95% [84.32–97.67]

T2: 100%

  1. PURE–LAMP procedure for ultra rapid extraction-loop-mediated isothermal amplification, RDT rapid diagnostic test, PCR polymerase chain reaction, CI confidence interval, Pan Plasmodium genus, Pf P. falciparum, T1 band of the rapid test containing the antibody for detection of a Plasmodium falciparum-specific HRP2 antigen, T2 band containing the antibody for detection of a Plasmodium common aldolase antigen
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Malaria Journal

ISSN: 1475-2875

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