Fig. 4From: A single nucleotide polymorphism in the Plasmodium falciparum atg18 gene associates with artemisinin resistance and confers enhanced parasite survival under nutrient deprivationAn atg18 T38I SNP is associated with higher IC50 values to ART derivatives ex vivo IC50 values for six anti-malarial drugs according to the presence of the atg18 T38I polymorphism and/or the polymorphism associated with resistance for that particular drug. a DHA and b artesunate are synthetic ART derivatives. IC50 values for ART derivatives are displayed against any K13-propeller mutation. c Mefloquine in the presence or absence of mdr copy number variations. d Piperaquine in the presence or absence of plasmepsins 2–3 copy number variations. e Chloroquine in the presence or absence of crt mutations. Given the single value in crtWT/atg18MT, it was not possible to statistically test for differences between this and the other groups. SCN denotes single copy number; ICN denotes increased copy numberBack to article page