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Table 3 Prevalence and incidence of asymptomatic P. falciparum parasitaemia at baseline and during tri-monthly follow-up

From: The dynamic of asymptomatic Plasmodium falciparum infections following mass drug administrations with dihydroarteminisin–piperaquine plus a single low dose of primaquine in Savannakhet Province, Laos

Variables

Village status

Baseline

Follow-up time

Over follow-up time

M0

M3

M6

M9

M12

Number of villagers*

Early MDA

859

745

801

792

808

 

Deferred-MDA

802

722

655

618

689

 

Number of Pf infections

Early MDA

41

0

9

5

6

 

Deferred-MDA

140

90

98

85

80

 

Pf prevalence, % and (95% CI)

Early MDA*

4.8 (3.4–6.4)

0 (0–0.5)

1.1 (0.5–2.1)

0.6 (0.2–1.5)

0.7 (0.3–1.6)

 

Deferred-MDA

17.5 (15.9–20)

12.5 (10.1–15.1)

15 (12.3–17.9)

13.8 (11.1–16.7)

11.6 (9.3–14.2)

 

Comparison between group, AOR (95% CI, p-value) **

   

0.18 (0.01–3.38, 0.254)

0.07 (0.01–1.26, 0.072)

0.13 (0.01–2.37, 0.170)

0.42 (0.01–12.28, 0.611)

Pf exposure time (person-years)

Early MDA

N/A

183

196

192

198

 

Deferred-MDA

N/A

176

159

151

167

 

Incidence of Pf infection (per 1000 person-years)

Early MDA

N/A

0 (0–20)

46 (21–87)

26 (8–61)

30 (11–66)

 

Deferred-MDA

N/A

510 (410–627)

617 (501–752)

563 (450–696)

478 (379–595)

 

Comparison between group, AIRR (95% CI, p-value)**

  

0.21 (0.01–3.08, 0.254)

0.09 (0.01–1.24, 0.071)

0.15 (0.01–2.24, 0.169)

0.08 (0.01–0.88, 0.039)

  1. *Significant declining over time in early MDA group, (AOR = 0.82, 95% CI 0.74–0.86, p-value < 0.001) but this was not significant in Non-MDA group, (AOR = 0.97, 95% CI 0.94–1.01, p-value = 0.101)
  2. **Adjusted for Pf prevalence at baseline (village level) and cluster (village) effect