Fig. 4

Multivariate correlation coefficients and networks in infected and non-infected individuals from Itaituba. Spearman’s correlation was applied to assess the association between the PvRON2 reactivity index with age, parasitaemia, platelets, RBC, hematocrit, hemoglobin, IL-6, IL-2, IL-10, IL-4, TNF-α and IFN-γ, and correlation networks were generated by the analysis of the relationship among each mediator measured in the plasma samples in a, b the infected group and c, d the non-infected group. Each connecting line (edge) represents a significant interaction (p < 0.05) detected by the network analysis using the R software. Correlation strength is represented by the tile or edge color transparency and width. Positive correlations are represented with red tiles/edges, and negatives correlations are represented with by blue tiles/edges