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Fig. 1 | Malaria Journal

Fig. 1

From: Analysis of erythrocyte dynamics in Rhesus macaque monkeys during infection with Plasmodium cynomolgi

Fig. 1

Scheme of the within-host host–pathogen interaction model. In the proposed model, reticulocytes (Ret) are released from the bone marrow at a rate of Pt cells/h/µL and with an age given by 121—ARRt hours, where ARRt stands for the age class into which reticulocytes are produced. All cells move from one age class to the next (right) at every hourly step. When reticulocytes reach their last age class, they mature into RBCs. In the absence of an infection, RBCs are removed at random or through senescence processes, in which older cells are more likely to be removed than young cells (depicted by the red bar over the RBC age classes). During an infection, merozoites (Mt) will, preferentially, invade reticulocytes and young RBCs (blue bars under the reticulocyte and RBCs pools). Upon infection, reticulocytes and RBCs become infected RBCs (iRBCi,t), which live for 24 h, after which they burst and release γ new merozoites. The immune response (It) removes infected RBCs in an age-independent way

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