Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity

Table 2 Selectivity indexes of extracts and fractions of Aspidosperma pyrifolium to three types of cells

Plant extract and fractions (code)	SI (MLD₅₀/IC₅₀)^a
Plant extract and fractions (code)	HepG2	BGM	PBMC
Stem bark (AP1)	137	333	333
Aqueous (AP2)	32	50	50
Organic (ethyl acetate) (AP3)	54	111	48
Stem (AP4)	24	59	24
Organic (ethyl acetate) (AP5)	53	167	26
Alkaloid-rich (AP5F.ALC)	84	200	29
Root bark (AP9)	29	21	21
Root (AP12)	23	56	22
Leaves	41	37	46

^aMLD₅₀ and IC₅₀ are shown in Table 1. SI was calculated only for the active samples

ISSN: 1475-2875