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Table 3 Anti-malarial activity of Aspidosperma pyrifolium against Plasmodium berghei in mice

From: Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity

Crude extracts and fractions (code)

% Reductiona

Day 5

Day 10

Extracts

 Root bark (AP9)

79

29

 Root (AP12)

75

52

 Leaves

23

40

Fractions

 Aqueous (AP2)

93

57

 Organic (ethyl acetate) (AP3)

0

34

 Alkaloid-rich (AP5F.ALC)

79

57

 Chloroquineb

100

100

  1. aReduction in parasitaemia compared to control infected non-treated mice; > 40% = active; 20–40% partially active; < 20% inactive. Results from one test, with exception of leaves extract that was tested three times
  2. bChloroquine was tested at 20 mg/kg