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Table 1 Proteins present in divergent levels in community controls compared to malaria patients

From: Levels of human proteins in plasma associated with acute paediatric malaria

Primary biological process Gene name Uniprot ID Gene description p-value Antibody
Cell migration and adhesion CCL5 P13501 CC motif chemokine ligand 5 1E−38 HPA010552+
CSF1 P09603 Colony stimulating factor 1 5E60 HPA061864+
IGFBP1 P08833 Insulin like growth factor binding protein 1 1E21 MAB675 R&D
ITGAV P06756 Integrin subunit alpha V 3E33 HPA004856
LCP1 P13796 Lymphocyte cytosolic protein 1 6E39 HPA019493+
SPARC P09486 Secreted protein acidic and cysteine rich 5E−26 HPA003020
VCAM1 P19320 Vascular cell adhesion molecule 1 2E74 HPA001618+
VWF P04275 von Willebrand factor 1E75 HPA002082+
Acute phase response CD14 P08571 CD14 molecule 6E31 HPA001887+
CEBPA P49715 CCAAT/enhancer binding protein alpha 5E83 HPA052734
CRP P02741 C-reactive protein 7E109 HPA027396+
LBP P18428 Lipopolysaccharide binding protein 4E87 HPA001508
ORM1/ORM2 P02763, P19652 Orosomucoid 1/2 5E27 HPA047725
SERPINA3 P01011 Serpin family A member 3 2E50 HPA002560+
TNF P01375 Tumor necrosis factor 3E43 HPA077901+
Apoptosis CTSD P07339 Cathepsin D 5E−15 HPA003001
RIPK2 O43353 Receptor interacting serine/threonine kinase 2 1E14 HPA016499
Erythrocyte associated EPB41L2 O43491 Erythrocyte membrane protein band 4.1 like 2 2E15 HPA006642+
GYPC P04921 Glycophorin C (Gerbich blood group) 2E28 HPA008965+
Tissue remodelling CALCA P01258 Calcitonin related polypeptide alpha 8E28 HPA064453
MMP2 P08253 Matrix metallopeptidase 2 2E42 HPA001939
Axon associated NEFM P07197 Neurofilament medium 8E16 HPA022845
DNA replication TIPIN Q9BVW5 TIMELESS interacting protein 4E19 HPA039704
Motor protein MYL3 P08590 Myosin light chain 3 3E18 HPA016564
Purine biosynthesis ADSSL1 Q8N142 Adenylosuccinate synthase like 1 4E55 HPA052621
T-cell response CD80 P33681 CD80 molecule 7E24 HPA039851
  1. Information about the 27 selected proteins (number of UniProt IDs) grouped on primary biological function with associated adjusted p-values based on t-test. Multiple proteins have previously been identified, by us and others, as having differential levels in malaria patients compared to controls and are marked [21, 32,33,34,35,36,37,38,39]. Proteins with lower levels in malaria cases compared to community controls are italicized. The proteins with support from multiple antibodies are marked + in the antibody column (see also Additional files 4, 11)