Skip to main content

Table 1 Proteins present in divergent levels in community controls compared to malaria patients

From: Levels of human proteins in plasma associated with acute paediatric malaria

Primary biological process

Gene name

Uniprot ID

Gene description

p-value

Antibody

Cell migration and adhesion

CCL5

P13501

C–C motif chemokine ligand 5

1E−38

HPA010552+

CSF1

P09603

Colony stimulating factor 1

5E−60

HPA061864+

IGFBP1

P08833

Insulin like growth factor binding protein 1

1E−21

MAB675 R&D

ITGAV

P06756

Integrin subunit alpha V

3E−33

HPA004856

LCP1

P13796

Lymphocyte cytosolic protein 1

6E−39

HPA019493+

SPARC

P09486

Secreted protein acidic and cysteine rich

5E−26

HPA003020

VCAM1

P19320

Vascular cell adhesion molecule 1

2E−74

HPA001618+

VWF

P04275

von Willebrand factor

1E−75

HPA002082+

Acute phase response

CD14

P08571

CD14 molecule

6E−31

HPA001887+

CEBPA

P49715

CCAAT/enhancer binding protein alpha

5E−83

HPA052734

CRP

P02741

C-reactive protein

7E−109

HPA027396+

LBP

P18428

Lipopolysaccharide binding protein

4E−87

HPA001508

ORM1/ORM2

P02763, P19652

Orosomucoid 1/2

5E−27

HPA047725

SERPINA3

P01011

Serpin family A member 3

2E−50

HPA002560+

TNF

P01375

Tumor necrosis factor

3E−43

HPA077901+

Apoptosis

CTSD

P07339

Cathepsin D

5E−15

HPA003001

RIPK2

O43353

Receptor interacting serine/threonine kinase 2

1E−14

HPA016499

Erythrocyte associated

EPB41L2

O43491

Erythrocyte membrane protein band 4.1 like 2

2E−15

HPA006642+

GYPC

P04921

Glycophorin C (Gerbich blood group)

2E−28

HPA008965+

Tissue remodelling

CALCA

P01258

Calcitonin related polypeptide alpha

8E−28

HPA064453

MMP2

P08253

Matrix metallopeptidase 2

2E−42

HPA001939

Axon associated

NEFM

P07197

Neurofilament medium

8E−16

HPA022845

DNA replication

TIPIN

Q9BVW5

TIMELESS interacting protein

4E−19

HPA039704

Motor protein

MYL3

P08590

Myosin light chain 3

3E−18

HPA016564

Purine biosynthesis

ADSSL1

Q8N142

Adenylosuccinate synthase like 1

4E−55

HPA052621

T-cell response

CD80

P33681

CD80 molecule

7E−24

HPA039851

  1. Information about the 27 selected proteins (number of UniProt IDs) grouped on primary biological function with associated adjusted p-values based on t-test. Multiple proteins have previously been identified, by us and others, as having differential levels in malaria patients compared to controls and are marked [21, 32,33,34,35,36,37,38,39]. Proteins with lower levels in malaria cases compared to community controls are italicized. The proteins with support from multiple antibodies are marked + in the antibody column (see also Additional files 4, 11)