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Table 2 Proteins present in divergent levels in mild compared to severe malaria cases

From: Levels of human proteins in plasma associated with acute paediatric malaria

Primary biological process Gene name Uniprot ID Gene description p-value Antibody
Cell migration and adhesion ADAMTS13 Q76LX8 ADAM metallopeptidase with thrombospondin type 1 motif 13 2E−02 HPA042014
CSF1 P09603 Colony stimulating factor 1 3E−02 HPA061864+
IGFBP1 P08833 Insulin like growth factor binding protein 1 3E−02 MAB675 R&D
ITGAV P06756 Integrin subunit alpha V 2E−02 HPA004856
VCAM1 P19320 Vascular cell adhesion molecule 1 2E−02 HPA069867+
VWF P04275 von Willebrand factor 4E−02 HPA002082
Erythrocyte associated ANK1 P16157 Ankyrin 1 5E−02 HPA004842
BPGM P07738 Bisphosphoglycerate mutase 1E−02 HPA016493
EPB41L2 O43491 Erythrocyte membrane protein band 4.1 like 2 3E−02 HPA005730
GYPC P04921 Glycophorin C (Gerbich blood group) 2E−02 HPA008965
HBA1/2 P69905 Hemoglobin subunit alpha 1/2 1E−02 HPA043780
MPP1 Q00013 Membrane palmitoylated protein 1 1E−02 HPA076675
Tissue remodelling AGT P01019 Angiotensinogen 3E−02 MAB3156 R&D
CA2 P00918 Carbonic anhydrase 2 7E−03 HPA071085
CALCA P01258 Calcitonin related polypeptide alpha 4E−02 HPA064453
ELANE P08246 Neutrophil elastase 1E−02 MAB91671 R&D
MMP2 P08253 Matrix metallopeptidase 2 2E−02 HPA001939
MMP9 P14780 Matrix metallopeptidase 9 3E−02 HPA001238
Acute phase response CD14 P08571 CD14 molecule 3E−02 HPA001887+
CEBPA P49715 CCAAT/enhancer binding protein alpha 3E−02 HPA052734
CRP P02741 C-reactive protein 3E−02 HPA027396
LBP P18428 Lipopolysaccharide binding protein 3E−02 HPA001508
TNF P01375 Tumour necrosis factor 5E−02 HPA077901+
Apoptosis DAPK1 P53355 Death associated protein kinase 1 3E−02 HPA040472
NGF P01138 Nerve growth factor 5E−02 HPA063135
RIPK2 O43353 Receptor interacting serine/threonine kinase 2 7E−03 HPA015764+
TNFRSF1B P20333 TNF receptor superfamily member 1B 2E−02 HPA004796
Axon associated HAP1 P54257 Huntingtin associated protein 1 3E−02 HPA053019
NEFM P07197 Neurofilament medium 3E−02 HPA022845
Motor protein MYL3 P08590 Myosin light chain 3 3E−02 HPA016564
MYO15A Q9UKN7 Myosin XVA 2E−02 HPA039770
T cell response CD80 P33681 CD80 molecule 2E−02 HPA039851
TNFSF13B Q9Y275 TNF superfamily member 13b 4E−02 HPA030526
Cell cycle regulation CDK14 O94921 Cyclin dependent kinase 14 3E−02 HPA015267
DNA replication TIPIN Q9BVW5 TIMELESS interacting protein 4E−02 HPA039704
Energy transduction CKB/CKM P12277, P06732 Creatine kinase B-type/M-type 4E−02 MAB5564 R&D
  1. Information about the 37 proteins (number of UniProt IDs) showing differential levels between patients with severe and mild malaria. Proteins are grouped on primary biological function with displayed adjusted p-values based on the Wilcoxon rank-sum test. All these proteins showed higher levels in severe compared to mild malaria cases and include proteins, previously identified by us, as associated with severe malaria have been marked [21]. Proteins supported by multiple antibodies are marked + in the antibody column (see also Additional files 5, 11)